Allergen-induced changes in bone marrow progenitors and airway responsiveness in dogs
| Autor: | Russ Ellis, Magnus Dahlbäck, M. J. Woolley, Judah A. Denburg, Paul M. O'Byrne |
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| Rok vydání: | 1995 |
| Předmět: |
Budesonide
Immunology Stem cell factor Granulocyte Colony-Forming Units Assay Dogs immune system diseases Bone Marrow Pregnenediones Administration Inhalation medicine Respiratory Hypersensitivity Immunology and Allergy Animals Progenitor cell Inhalation business.industry General Medicine respiratory system Airway obstruction Allergens medicine.disease respiratory tract diseases Hematopoiesis Airway Obstruction Haematopoiesis medicine.anatomical_structure Bone marrow business medicine.drug Granulocytes |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1018-2438 |
| Popis: | An increased production of inflammatory cell progenitors (colony-forming cells, CFUs) may contribute to airway inflammation, since CFUs increase after allergen inhalation in asthmatics. We examined the effect of allergen inhalation, with or without budesonide pretreatment, on bone marrow CFU production in dogs with allergen-induced airway hyperresponsiveness. Allergen inhalation increased airway responsiveness (p < 0.001) as well as the number of CFUs induced in vitro by recombinant canine stem cell factor (p < 0.001) and granulocyte-colony-stimulating factor (p = 0.035). Budesonide reduced the allergen-induced increases in airway responsiveness (p = 0.005) and abolished the allergen-induced increases in the numbers of CFUs (p < 0.005). These findings provide the first direct evidence that allergen inhalation increases bone marrow granulocyte progenitor production and suggest that such increases may contribute to the development of airway hyperresponsiveness in asthma. The effectiveness of inhaled corticosteroids in asthma may result, in part, from effect on bone marrow production of inflammatory cells. |
| Databáze: | OpenAIRE |
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