A Subanesthetic Concentration of Sevoflurane Increases Regional Cerebral Blood Flow and Regional Cerebral Blood Volume and Decreases Regional Mean Transit Time and Regional Cerebrovascular Resistance in Volunteers
| Autor: | Fritz Zschiegner, Stephan Felber, Alexander Löckinger, Christoph Hörmann, Karl P. Pfeiffer, Ingo H. Lorenz, Michael Schocke, Arnulf Benzer, Christian Kremser, Christian Kolbitsch |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Gadolinium DTPA Male Methyl Ethers Hemodynamics Contrast Media Blood volume Vasodilation Sevoflurane Medicine Humans Blood Volume business.industry Echo-Planar Imaging Blood flow Magnetic Resonance Imaging medicine.anatomical_structure Anesthesiology and Pain Medicine Cerebral blood flow Anesthesia Cerebrovascular Circulation Anesthetics Inhalation Vascular resistance Vascular Resistance business Perfusion medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 91:156-162 |
| ISSN: | 0003-2999 |
| Popis: | Inhaled anesthetics exert metabolically mediated effects on cerebral blood vessels both directly and indirectly. We investigated the effects of a 0.4 minimum alveolar subanesthetic concentration of sevoflurane on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), regional cerebrovascular resistance (rCVR), and regional mean transit time (rMTT) in volunteers by means of contrast-enhanced magnetic resonance imaging perfusion measurement. Sevoflurane increased rCBF by 16% to 55% (control, 55. 03 +/- 0.33 to 148.83 +/- 1.9 mL. 100 g(-1). min(-1); sevoflurane, 71.75 +/- 0.36 to 193.26 +/- 2.14 mL. 100 g(-1). min(-1)) and rCBV by 7% to 39% (control, 4.66 +/- 0.03 to 10.04 +/- 0.12 mL/100 g; sevoflurane, 5.04 +/- 0.03 to 13.6 +/- 0.15 mL/100 g); however, sevoflurane decreased rMTT by 7% to 18% (control, 3.75 +/- 0.04 to 5. 39 +/- 0.04 s; sevoflurane, 3.4 +/- 0.03 to 4.44 +/- 0.03 s) and rCVR by 22% to 36% (control, 0.74 +/- 0.01 to 1.9 +/- 0.2 mm Hg/[mL. 100 g(-1). min(-1)]; sevoflurane, 0.54 +/- 0.01 to 1.41 +/- 0.01 mm Hg/[mL. 100 g(-1). min(-1)]). Interhemispheric differences in rCBF, rCBV, and rCVR were markedly reduced after the administration of sevoflurane. These findings are consistent with the known direct vasodilating effect of sevoflurane. The decrease in rMTT further shows that rCBF increases more than does rCBV. Furthermore, we can show that the observed increase in rCBF during inhalation of sevoflurane is not explained by vasodilation alone. |
| Databáze: | OpenAIRE |
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