The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?
| Autor: | Shahd Abureesh, Rola Hassan, Shuruq Alghamdi, Rbab Taha, Rania A Bagabir, Mohamed Cheikh, Altaf Abdulkhaliq, Hani Almoallim |
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| Rok vydání: | 2021 |
| Předmět: |
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25-dihydroxyvitamin D Tuberculosis Inflammation Review severe acute respiratory syndrome vitamin D deficiency Immune system Pandemic medicine Vitamin D and neurology SARS 25(OH)D human immunodeficiency virus business.industry Mechanism (biology) HIV COVID-19 Mycobacterium tuberculosis General Medicine medicine.disease Acquired immune system 25-hydroxyvitamin D 1 25(OH)2D TB tuberculosis MTB Immunology medicine.symptom influenza business |
| Zdroj: | International Journal of General Medicine |
| ISSN: | 1178-7074 |
| DOI: | 10.2147/ijgm.s317421 |
| Popis: | Vitamin D is proposed to have a potential role in the pathogenicity, clinical presentation, prognosis, complications, and treatment of several diseases. In addition to its well-known role in calcium metabolism, vitamin D regulates both innate and adaptive immunity, and subsequently modulates the antiviral and antibacterial inflammatory immune responses. In view of the emerging coronavirus disease 2019 (COVID-19) pandemic, searching for potential therapeutic and protective strategies is of urgent interest, and vitamin D is one of the promising agents in this field. In this review, we present data from literature that supports the promising role of vitamin D in treatment and/or prevention of several infections including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review summarizes vitamin D metabolism and its role in inflammation, thrombosis and immune regulation. It also reviews, in short, the role of vitamin D and the impact of its deficiency in several infections namely tuberculosis, influenza, human immunodeficiency virus (HIV), and SARS-CoV-2. Considering the roles of vitamin D on immune modulation, controlling of thrombosis, and attacking several microorganisms, the current review will elaborate on the association between these salient roles of vitamin D and the pathogenicity of various infectious agents including COVID-19. Consequently, the comprehensive finding of the current review shows a possible significant impact of vitamin D supplement as a hope in preventing, treating, and/or improving the progression of certain infections, specifically during the worldwide attempts to fight against the COVID-19 pandemic and minimize the severity of health complications encountered accordingly. In addition, avoiding a status of vitamin D deficiency to obtain its positive effects on the immune system and its protective mechanism during infections will be a general benefit overall. |
| Databáze: | OpenAIRE |
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