Necroptosis: Biochemical, Physiological and Pathological Aspects
| Autor: | Pal I. Bauer, Zsuzsanna A. Dunai, Rudolf Mihalik |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
Programmed cell death Necrosis Necroptosis Cell Apoptosis Receptors Death Domain General Medicine Biology Pathology and Forensic Medicine Cell biology RIPK1 medicine.anatomical_structure Oncology Virus Diseases Caspases medicine Animals Humans Signal transduction medicine.symptom Tissue homeostasis Signal Transduction |
| Zdroj: | Pathology & Oncology Research. 17:791-800 |
| ISSN: | 1532-2807 1219-4956 |
| DOI: | 10.1007/s12253-011-9433-4 |
| Popis: | Programmed cell death is a key component of tissue homeostasis, normal development and wide variety of diseases. Conventional view refers to programmed cell death form as caspase-mediated apoptosis while necrosis is considered as an accidental and unwanted cell demise, carried out in a non-regulated manner and caused by extreme conditions. However, accumulating evidences indicate that necrotic cell death can also be a regulated process. The term necroptosis has been introduced to describe a cell death receptor-induced, caspase-independent, highly regulated type of programmed cell death process with morphological resemblance of necrosis. Necroptosis recently has been found to contribute to a wide range of pathologic cell death forms including ischemic brain injury, neurodegenerative diseases and viral infection, therefore a better understanding of the necroptotic signaling machinery has clinical relevance. |
| Databáze: | OpenAIRE |
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