BIOLOGICAL ACTIVE COMPONENTS OF SILENE TOMENTELLA AND THEIR PHARMACOLOGICAL PROPERTIES
| Autor: | F. R. Égamova, Vladimir Nikolaevich Syrov, Khairulla Mamadievich Bobakulov, Nurmurod Sheralievich Ramazonov, Ugiloy Yusufovna Yusupova, D. A. Usmanov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
medicine.medical_treatment Plant Science 01 natural sciences hypoglycemic and antioxidant activities Biomaterials chemistry.chemical_compound phytoecdysteroids (PE) medicine Silene tomentella chemistry.chemical_classification Silene Pinitol biology Glycogen 010405 organic chemistry Organic Chemistry biology.organism_classification Bioactive compound 0104 chemical sciences 010404 medicinal & biomolecular chemistry Enzyme chemistry Biochemistry Catalase biology.protein D-pinitol Tomentella |
| Zdroj: | chemistry of plant raw material; No 1 (2021); 197-202 Химия растительного сырья; № 1 (2021); 197-202 |
| ISSN: | 1029-5151 1029-5143 |
| Popis: | In thepresent investigation isolation of chemical compounds was carried out from the aerial part of Silene tomentella, an evergreen member of the family Caryophyllaceae, using column chromatography. Identification of chemical compounds was done by various MP, TLC, IR, NMR techniques. The presence of the bioactive compound D-pinitol in this plant is being reported for the first time. Under the influence of D-pinitol, a clear tendency towards normalization of the glycogen content in the liver was also noted (it was only 10.4% lower than in intact animals). In the liver of animals, a rather sharp decrease in the content of glycogen was noted – by 63.5%, and a decrease in the activity of enzymes of the antioxidant defense of the body, characteristic of developing diabetes: SOD – by 35.1, and catalase – by 32.4%. Prophylactically – therapeutic administration of D- pinitol, which exhibits a pronounced ability to inhibit free radical oxidation processes. |
| Databáze: | OpenAIRE |
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