High expression of Myosin 1g in pediatric acute lymphoblastic leukemia
| Autor: | Juan D. Diaz-Valencia, Janeth E Araujo-Cardenas, Laura A Estrada-Abreo, Genaro Patino-Lopez, Darío Orozco-Ruiz, Leonor Rodríguez-Cruz, Alfonso R Salgado-Aguayo, Sara Huerta-Yepez, José Refugio Torres-Nava, Yanelly Garfias-Gómez, Gabriela Antonio-Andres |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.diagnostic_test business.industry Cancer Disease acute lymphoblastic leukemia high risk Immunofluorescence medicine.disease Peripheral blood mononuclear cell Pathogenesis Haematopoiesis pediatric Internal medicine Myosin Medicine Biomarker (medicine) biomarker Myosin 1g business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Acute Lymphoblastic Leukemia (ALL) is the most frequent cancer in pediatric population. Although the treatment has improved and almost 85% of the children are cured about 20% suffer relapse, therefore finding molecules that participate in the pathogenesis of the disease for the identification of relapse and patients at risk is an urgent unmet need. Class I myosins are molecular motors involved in membrane tension, endocytosis, phagocytosis and cell migration and recently they have been shown important for development and aggressiveness of diverse cancer types, however Myo1g an hematopoietic specific myosin has not been studied in cancer so far. We evaluated the expression of Myo1g by qRT-PCR, Immunocytochemistry and Immunofluorescence in a cohort of 133 ALL patients and correlated the expression at diagnosis and after treatment with clinical features and treatment outcomes. We found high expression levels of Myo1g in Peripheral Blood Mononuclear Cells (PBMCs) from patients with ALL at diagnosis and those levels decreased after complete remission; furthermore, we found an increase in Myo1g expression on patients with 9:22 translocation and those who relapse. This study show that Myo1g is over expressed in ALL and that may participate in the pathogenesis of the disease specially in high-risk patients. |
| Databáze: | OpenAIRE |
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