Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)
| Autor: | Paul A. Decker, S. J. Bielinski, Naomi Q. Hanson, James S. Pankow, Alka M. Kanaya, Weihong Tang, Michael Y. Tsai, Nicholas B. Larson, Christina L. Wassel, Michèle M. Sale, C. Berardi |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
Male Aging Endocrinology Diabetes and Metabolism 030204 cardiovascular system & hematology Cardiovascular Cohort Studies 0302 clinical medicine Endocrinology Psychology Prospective Studies Endothelial dysfunction L-Selectin Prospective cohort study biology Cell adhesion molecule Incidence Hazard ratio Diabetes Middle Aged Cadherins Intercellular Adhesion Molecule-1 CD P-Selectin Public Health and Health Services L-selectin Female E-Selectin Type 2 Risk medicine.medical_specialty Clinical Sciences Vascular Cell Adhesion Molecule-1 030209 endocrinology & metabolism Article 03 medical and health sciences Endocrinology & Metabolism Antigens CD Clinical Research Internal medicine Diabetes mellitus Internal Medicine medicine Diabetes Mellitus Humans Antigens Cell adhesion Metabolic and endocrine Proportional Hazards Models Nutrition Proportional hazards model business.industry Prevention medicine.disease Atherosclerosis United States Diabetes Mellitus Type 2 Immunology biology.protein business |
| Zdroj: | Diabetic medicine : a journal of the British Diabetic Association, vol 33, iss 7 |
| Popis: | Aims To test the hypothesis that soluble cellular adhesion molecules would be positively and independently associated with risk of diabetes. Methods Soluble levels of six cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1, E-cadherin, L-selectin and P-selectin) were measured in participants in the Multi-Ethnic Study of Atherosclerosis, a prospective cohort study. Participants were then followed for up to 10 years to ascertain incident diabetes. Results Sample sizes ranged from 826 to 2185. After adjusting for age, sex, race/ethnicity, BMI and fasting glucose or HbA1c, four cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1 and E-cadherin) were positively associated with incident diabetes and there was a statistically significant trend across quartiles. Comparing the incidence of diabetes in the highest and lowest quartiles of each cellular adhesion molecule, the magnitude of association was largest for E-selectin (hazard ratio 2.49; 95% CI 1.26–4.93) and ICAM-1 (hazard ratio 1.76; 95% CI 1.22–2.55) in fully adjusted models. Tests of effect modification by racial/ethnic group and sex were not statistically significant for any of the cellular adhesion molecules (P > 0.05). Conclusions The finding of significant associations between multiple cellular adhesion molecules and incident diabetes may lend further support to the hypothesis that microvascular endothelial dysfunction contributes to risk of diabetes. |
| Databáze: | OpenAIRE |
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