Enhanced chlorhexidine skin penetration with 1,8-cineole
| Autor: | Tony Worthington, Ruth Waters, Tom S.J. Elliott, Anna L. Casey, Peter Nightingale, Barbara R. Conway, Tarja J. Karpanen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty RM Skin Absorption 030106 microbiology Human skin 030501 epidemiology High-performance liquid chromatography lcsh:Infectious and parasitic diseases RS 2-Propanol 03 medical and health sciences chemistry.chemical_compound Skin surface Medicine Humans lcsh:RC109-216 Chromatography Eucalyptol integumentary system business.industry Chlorhexidine Isopropyl alcohol Permeation Middle Aged Cyclohexanols Antiseptic penetration Solutions Infectious Diseases chemistry Skin penetration Terpene Anti-Infective Agents Local Monoterpenes Skin antisepsis Full thickness Female 0305 other medical science business medicine.drug Research Article |
| Zdroj: | BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-5 (2017) BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| Popis: | Background\ud Chlorhexidine (CHG) penetrates poorly into skin. The purpose of this study was to compare the depth of CHG skin permeation from solutions containing either 2% (w/v) CHG and 70% (v/v) isopropyl alcohol (IPA) or 2% (w/v) CHG, 70% (v/v) IPA and 2% (v/v) 1,8-cineole.\ud \ud Methods\ud An ex-vivo study using Franz diffusion cells was carried out. Full thickness human skin was mounted onto the cells and a CHG solution, with or without 2% (v/v) 1,8-cineole was applied to the skin surface. After twenty-four hours the skin was sectioned horizontally in 100 μm slices to a depth of 2000 μm and the concentration of CHG in each section quantified using high performance liquid chromatography (HPLC). The data were analysed with repeated measures analysis of variance.\ud \ud Results\ud The concentration of CHG in the skin on average was significantly higher (33.3% [95%, CI 1.5% - 74.9%]) when a CHG solution which contained 1,8-cineole was applied to the skin compared to a CHG solution which did not contain this terpene (P = 0.042).\ud \ud Conclusions\ud Enhanced delivery of CHG can be achieved in the presence of 1,8-cineole, which is the major component of eucalyptus oil. This may reduce the numbers of microorganisms located in the deeper layers of the skin which potentially could decrease the risk of surgical site infection. |
| Databáze: | OpenAIRE |
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