A Triad of Crystals Sheds Light on MDGA Interference with Neuroligation

Autor: Pascale Marchot, Olivier Thoumine
Přispěvatelé: Physiologie cellulaire de la synapse (PCS), Université Bordeaux Segalen - Bordeaux 2-Institut François Magendie-Centre National de la Recherche Scientifique (CNRS), Architecture et fonction des macromolécules biologiques (AFMB), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), ANR-17-CE16-0028,SyntheSyn,Contrôle optique de la fonction synaptique via les molécules d'adhésion(2017), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Cell Adhesion Molecules
Neuronal
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Galactosamine
Neuronal metabolism
Biology
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
MESH: Synapses
Synapse
03 medical and health sciences
Triad (sociology)
MESH: Activated-Leukocyte Cell Adhesion Molecule
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Activated-Leukocyte Cell Adhesion Molecule
Animals
MESH: Animals
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
MESH: Galactosamine
MESH: Cell Adhesion Molecules
Neuronal
MESH: Dansyl Compounds
Dansyl Compounds
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Structural Biology [q-bio.BM]
General Neuroscience
MESH: Multiprotein Complexes
[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biomolecules [q-bio.BM]
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biomolecules [q-bio.BM]
030104 developmental biology
Multiprotein Complexes
Synapses
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Neuroscience
Zdroj: Neuron
Neuron, Elsevier, 2017, 95 (4), pp.729-732. ⟨10.1016/j.neuron.2017.08.001⟩
Neuron, 2017, 95 (4), pp.729-732. ⟨10.1016/j.neuron.2017.08.001⟩
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2017.08.001⟩
Popis: International audience; Neurexins and neuroligins form trans-synaptic complexes that promote synapse development. In this issue of Neuron, Aricescu and colleagues (Elegheert et al., 2017) complement and strengthen two recent reports by the Kim and Rudenko teams (Kim et al., 2017; Gangwar et al., 2017) to dissect the molecular determinants by which MDGAs challenge the neurexin-neuroligin partnership.
Databáze: OpenAIRE
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