Differential expression of TGFBR3 (betaglycan) in mouse ovary and testis during gonadogenesis

Autor:	Mai A. Sarraj, Hui Kheng Chua, Alexandra Umbers, Kate L. Loveland, Jock K. Findlay, Kaye L. Stenvers
Rok vydání:	2007
Předmět:	Male medicine.medical_specialty Gonad Somatic cell Clinical Biochemistry Ovary Biology Andrology Mice Endocrinology Internal medicine Testis Morphogenesis medicine Animals RNA Messenger Receptor Messenger RNA Fetus Leydig cell Cell Biology Mice Inbred C57BL medicine.anatomical_structure Female Proteoglycans Receptors Transforming Growth Factor beta Germ cell
Zdroj:	Growth Factors. 25:334-345
ISSN:	1029-2292 0897-7194
DOI:	10.1080/08977190701833619
Popis:	TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFbeta) and inhibin, two members of the TGFbeta superfamily of growth factors that regulate many aspects of reproductive biology. Tgfbr3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis. Herein, we describe Tgfbr3 expression in the male and female fetal and neonatal murine gonad. Real-time PCR analysis revealed that Tgfbr3 mRNA was expressed at higher levels in the developing testis compared to ovary. TGFBR3 was expressed within the fetal testis interstitium, predominantly by Leydig cells, but expression shifted inside the seminiferous cords at birth. In contrast, TGFBR3 was detected in both the somatic and germ cell lineages in the fetal and neonatal ovary. This differential expression pattern suggests divergent roles for this TGFBR3 in developing testis and ovary.
Databáze:	OpenAIRE
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