Antioxidant-Rich Diet Relieves Hypertension and Reduces Renal Immune Infiltration in Spontaneously Hypertensive Rats
| Autor: | Ram K. Sindhu, Yasmir Quiroz, Nosratola D. Vaziri, Chang-De Zhan, Bernardo Rodriguez-Iturbe |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Kidney Glomerulus Blood Pressure Inflammation Ascorbic Acid Kidney medicine.disease_cause Rats Inbred WKY Antioxidants chemistry.chemical_compound Pregnancy Malondialdehyde Rats Inbred SHR Internal medicine Renin–angiotensin system Internal Medicine medicine Animals Vitamin E Lymphocytes cardiovascular diseases business.industry Macrophages Nitrotyrosine Kidney metabolism Hydrogen Peroxide musculoskeletal system medicine.disease Diet Rats medicine.anatomical_structure Endocrinology Blood pressure chemistry Hypertension cardiovascular system Female medicine.symptom business Infiltration (medical) Oxidative stress circulatory and respiratory physiology |
| Zdroj: | Hypertension. 41:341-346 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.0000052833.20759.64 |
| Popis: | Previous studies have demonstrated that oxidative stress contributes to hypertension and treatments with either antioxidant or immunosuppressive/anti-inflammatory agents improve hypertension in spontaneously hypertensive rats (SHR). The present study was performed to determine if the antihypertensive effects of an antioxidant-rich diet are associated with reduction in the renal immune infiltration. Rats were divided into experimental groups (n=5 each) that were followed 7 months after birth, during which they were fed either a regular or antioxidant-enriched (test) diet as follows: SHR-R group=regular diet; SHR-T group=test diet throughout the experiment; SHR-S group=test diet for 4 months switched to regular diet thereafter; WKY group=control rats given regular diet. The SHR-T rats showed a significant reduction in systolic blood pressure (mm Hg): SHR-T=179.6±12.9 versus SHR-R=207.5±9.6 ( P 2 ) of lymphocytes (SHR-T=18±3 versus SHR-R=30±4, P P |
| Databáze: | OpenAIRE |
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