Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct : A Mendelian Randomization Study
| Autor: | Nita G. Forouhi, Kim Overvad, Aurelio Barricarte, Rudolf Kaaks, Kay-Tee Khaw, J. Ramón Quirós, Yvonne T. van der Schouw, Guy Fagherazzi, Elio Riboli, Olatz Mokoroa, Peter M. Nilsson, Valeria Pala, Claudia Langenberg, Heinz Freisling, Tilman Kühn, Timothy J. Key, Maria Dolores Chirlaque, Paul W. Franks, Domenico Palli, Nicholas J. Wareham, Annemieke M.W. Spijkerman, Catalina Bonet, Miguel Rodríguez-Barranco, Olov Rolandsson, Stephen Burgess, Ivonne Sluijs, Carlotta Sacerdote, Heiner Boeing, Anne Tjønneland, Stephen J. Sharp, Salvatore Panico, Marc J. Gunter, Daniel B Ibsen, Fumiaki Imamura, Rosario Tumino, Linda E.T. Vissers |
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| Přispěvatelé: | Vissers, Linda ET [0000-0001-9044-0744], Sluijs, Ivonne [0000-0001-7758-4911], Forouhi, Nita G [0000-0002-5041-248X], Fagherazzi, Guy [0000-0001-5033-5966], Franks, Paul W [0000-0002-0520-7604], Khaw, Kay T [0000-0002-8802-2903], Apollo - University of Cambridge Repository, Commission of the European Communities |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism Type 2 diabetes LACTASE PERSISTENCE Cohort Studies Eating 0302 clinical medicine Endocrinology Risk Factors Neoplasms Medicine 030212 general & internal medicine Advanced and Specialised Nursing Lactase Incidence Mendelian Randomization Analysis 11 Medical And Health Sciences Middle Aged PROSTATE-CANCER Diabetes and Metabolism Milk NUTRITION Female HEALTH Cohort study Adult Genotype GENETIC VARIANT QUESTIONNAIRE 030209 endocrinology & metabolism Single-nucleotide polymorphism Polymorphism Single Nucleotide Article Endocrinology & Metabolism 03 medical and health sciences Diabetes mellitus Environmental health Mendelian randomization Internal Medicine Journal Article Animals Humans Product (category theory) VALIDITY Advanced and Specialized Nursing business.industry Case-control study CONSUMPTION medicine.disease Nutrition Assessment Diabetes Mellitus Type 2 Case-Control Studies Gene-Environment Interaction Dairy Products business |
| Zdroj: | Vissers, L E T, Sluijs, I, van der Schouw, Y T, Forouhi, N G, Imamura, F, Burgess, S, Barricarte, A, Boeing, H, Bonet, C, Chirlaque, M-D, Fagherazzi, G, Franks, P W, Freisling, H, Gunter, M J, Quirós, J R, Ibsen, D B, Kaaks, R, Key, T, Khaw, K T, Kühn, T, Mokoroa, O, Nilsson, P M, Overvad, K, Pala, V, Palli, D, Panico, S, Sacerdote, C, Spijkerman, A M W, Tjonneland, A, Tumino, R, Rodríguez-Barranco, M, Rolandsson, O, Riboli, E, Sharp, S J, Langenberg, C & Wareham, N J 2019, ' Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct : A Mendelian Randomization Study ', Diabetes Care, vol. 42, no. 4, pp. 568-575 . https://doi.org/10.2337/dc18-2034 Diabetes Care Diabetes Care, 42(4), 568. American Diabetes Association Inc. |
| ISSN: | 0149-5992 |
| DOI: | 10.2337/dc18-2034 |
| Popis: | OBJECTIVE To estimate the causal association between intake of dairy products and incident type 2 diabetes. RESEARCH DESIGN AND METHODS The analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a single nucleotide polymorphism (SNP) for lactase persistence (LP) that enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression. RESULTS Each additional LP allele was associated with a higher intake of milk (β 17.1 g/day, 95% CI 10.6–23.6) and milk beverages (β 2.8 g/day, 95% CI 1.0–4.5) but not with intake of other dairy products. Other dietary intakes associated with rs4988235 included fruits (β −7.0 g/day, 95% CI −12.4 to −1.7 per additional LP allele), nonalcoholic beverages (β −18.0 g/day, 95% CI −34.4 to −1.6), and wine (β −4.8 g/day, 95% CI −9.1 to −0.6). In instrumental variable analysis, LP-associated milk intake was not associated with diabetes (hazard ratioper 15 g/day 0.99, 95% CI 0.93–1.05). CONCLUSIONS rs4988235 was associated with milk intake but not with intake of other dairy products. This MR study does not suggest that milk intake is associated with diabetes, which is consistent with previous observational and genetic associations. LP may be associated with intake of other foods as well, but owing to the modest associations, we consider it unlikely that this caused the observed null result. |
| Databáze: | OpenAIRE |
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