Apoptosis markers related to pathogenesis of pediatric chronic hepatitis C virus infection: M30 mirrors the severity of steatosis
| Autor: | Pamela Valva, Elena Noemí de Matteo, María Cristina Galoppo, M.V. Preciado, María I. Gismondi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent Hepatitis C virus Biopsy Apoptosis Biology Viral Nonstructural Proteins medicine.disease_cause Blood serum Virology medicine In Situ Nick-End Labeling Humans Fat Necrosis Child Liver injury medicine.diagnostic_test Keratin-18 Caspase 3 Histocytochemistry Fatty liver Infant Hepatitis C Hepatitis C Chronic medicine.disease Immunohistochemistry Infectious Diseases Liver Liver biopsy Child Preschool Female Steatosis Viral hepatitis Biomarkers |
| Zdroj: | Journal of medical virology. 82(6) |
| ISSN: | 1096-9071 |
| Popis: | Apoptosis involvement in liver damage related to hepatitis C virus (HCV) chronic infection has been suggested. Although liver biopsy represents the gold standard for evaluating disease severity, non-invasive tests are a growing medical need. The aim of this study was to detect apoptosis markers in liver and serum from pediatric HCV-infected patients and to assess its utility to predict liver damage progression. Twenty-three patients were included. Liver biopsies were used for histological analysis as well as for immunodetection of a viral protein (NS3) and apoptosis markers (activated caspase-3 [casp-3a], caspase-generated CK-18 fragment [M30] and TUNEL). M30 was quantified in paired serum and biopsy samples. NS3 correlated both with casp-3a (r = 0.83, P |
| Databáze: | OpenAIRE |
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