Anaphylactoid Reaction to Intravenous Acetylcysteine Associated with Electrocardiographic Abnormalities
| Autor: | Bradley R. Martin, Darrell T. Hulisz, Sheldon M. Traeger, Mark F. Bonfiglio |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Tachycardia acetaminophen overdose Chest pain Drug overdose 030226 pharmacology & pharmacy Acetylcysteine Electrocardiography 03 medical and health sciences 0302 clinical medicine medicine Humans ST segment Pharmacology (medical) 030212 general & internal medicine Infusions Intravenous Anaphylaxis Acetaminophen medicine.diagnostic_test business.industry medicine.disease Anesthesia Etiology Female Drug Overdose medicine.symptom business medicine.drug |
| Zdroj: | Annals of Pharmacotherapy. 26:22-25 |
| ISSN: | 1542-6270 1060-0280 |
| DOI: | 10.1177/106002809202600105 |
| Popis: | OBJECTIVE:To review the potential for anaphylactoid reactions to intravenously administered acetylcysteine when used in the treatment of acetaminophen overdose. This case is unique in that electrocardiographic changes, including ST segment depression and T-wave inversion were associated with the episode and complicated the diagnosis.DATA SOURCES:Reference articles and letters are identified in the text.DATA SYNTHESIS:Intravenous administration of acetylcysteine has been used in the treatment of acetaminophen overdose. This route may be considered in some clinical situations where oral therapy is complicated. Anaphylactoid reactions, including cutaneous eruptions, flushing, chest pain, tachycardia, and fever have been reported in up to three percent of patients receiving intravenous acetylcysteine. The nature of these reactions and evidence concerning their etiology suggest a histamine-release phenomenon. Response to intervention with antihistamines and the safety of further acetylcysteine administration are discussed.CONCLUSIONS:This case illustrates a variant anaphylactoid reaction to intravenously administered acetylcysteine and emphasizes the need for practitioners to consider the potential for these reactions prior to initiation of therapy and indicates appropriate treatment of these reactions. |
| Databáze: | OpenAIRE |
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