Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome
| Autor: | Wijnand Laan, Laura Bakker, André J P M Smout, Niek J. de Wit, Carla E. Flik, Yanda R. van Rood |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Systematic Reviews medicine.medical_treatment Psychological interventions Treatment outcome Psychological intervention Placebo medicine.disease_cause 03 medical and health sciences Young Adult 0302 clinical medicine Quality of life medicine Psychological stress Humans Young adult Irritable bowel syndrome Aged Randomized Controlled Trials as Topic Cognitive Behavioral Therapy Placebo effect business.industry digestive oral and skin physiology Gastroenterology General Medicine Middle Aged medicine.disease digestive system diseases Treatment Outcome Cognitive therapy Physical therapy Quality of Life Systematic review 030211 gastroenterology & hepatology Female business Psychotherapy Psychodynamic 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | World Journal of Gastroenterology, 23(12), 2223-2233 World Journal of Gastroenterology |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v23.i12.2223 |
| Popis: | AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions (stress management/relaxation therapy (cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome (IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching PubMed, Embase, the Cochrane Library, CINAHL and PsycINFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate (PRR) was computed for IBS symptom severity (primary outcome measure) as well as for anxiety, depression and quality of life (secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical interventions. CONCLUSION The PRR is probably determined to a larger extent by patient-related factors, such as expectations and desire for the treatment to be effective, than the content of the placebo intervention. |
| Databáze: | OpenAIRE |
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