Japanese encephalitis virus–primed CD8+ T cells prevent antibody-dependent enhancement of Zika virus pathogenesis
| Autor: | Yanjun Zhang, Xinyu Chen, Shengwei Jin, Dong Chen, Lan Yang, Zhiliang Duan, Weiwei Zou, Jinsheng Wen, Yongchao Zhou, Dezhou Li, Sujan Shresta, Wenhua Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
viruses 030231 tropical medicine Immunology CD8-Positive T-Lymphocytes Cross Reactions Antibodies Viral Article Virus Cell Line Zika virus Infectious Disease and Host Defense Epitopes Young Adult 03 medical and health sciences 0302 clinical medicine Immune system Immunity medicine Animals Humans Immunology and Allergy Cytotoxic T cell Antibody-dependent enhancement Amino Acid Sequence Child Encephalitis Japanese Encephalitis Virus Japanese biology Zika Virus Infection Immune Sera Infant Zika Virus Japanese encephalitis biology.organism_classification medicine.disease Antibodies Neutralizing Antibody-Dependent Enhancement Virology Mice Inbred C57BL 030104 developmental biology Animals Newborn Immunoglobulin G Viral load |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Chen et al. show that Japanese encephalitis virus (JEV)–elicited CD8+ T cells and antibodies play protective and pathogenic roles in Zika virus–infected wild-type C57BL/6 mice, respectively, and JEV-elicited CD8+ T cells abrogate anti-JEV antibody–mediated enhancement of Zika virus infection in mice. Cross-reactive anti-flaviviral immunity can influence the outcome of infections with heterologous flaviviruses. However, it is unclear how the interplay between cross-reactive antibodies and T cells tilts the balance toward pathogenesis versus protection during secondary Zika virus (ZIKV) and Japanese encephalitis virus (JEV) infections. We show that sera and IgG from JEV-vaccinated humans and JEV-inoculated mice cross-reacted with ZIKV, exacerbated lethal ZIKV infection upon transfer to mice, and promoted viral replication and mortality upon ZIKV infection of the neonates born to immune mothers. In contrast, transfer of CD8+ T cells from JEV-exposed mice was protective, reducing the viral burden and mortality of ZIKV-infected mice and abrogating the lethal effects of antibody-mediated enhancement of ZIKV infection in mice. Conversely, cross-reactive anti-ZIKV antibodies or CD8+ T cells displayed the same pathogenic or protective effects upon JEV infection, with the exception that maternally acquired anti-ZIKV antibodies had no effect on JEV infection of the neonates. These results provide clues for developing safe anti-JEV/ZIKV vaccines. Graphical Abstract |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|