Scotin: A new p63 target gene expressed during epidermal differentiation
| Autor: | Gerry Melino, Jean-Christophe Bourdon, Andrea Codispoti, Loredana Zocchi, David P. Lane, Richard A. Knight, Alessandro Terrinoni |
|---|---|
| Přispěvatelé: | Simon, Marie Francoise, IDI-IRCCS Biochemistry Laboratory, Università degli Studi di Roma Tor Vergata [Roma], Inserm European Associated Laboratory, University of Dundee, Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Medical Research Council, Toxicology Unit, University of Leicester |
| Rok vydání: | 2008 |
| Předmět: |
Keratinocytes
MESH: Cell Differentiation Cellular differentiation Biophysics Biology Endoplasmic Reticulum Biochemistry Article MESH: Animals Newborn Mice Transactivation Downregulation and upregulation MESH: Endoplasmic Reticulum Epithelial differentiation MESH: Gene Expression Regulation Developmental medicine ER stress GADD153 p63 Scotin Animals MESH: Animals Nuclear membrane MESH: Mice Transcription factor Molecular Biology Cells Cultured MESH: Oxidative Stress Settore BIO/11 Endoplasmic reticulum Gene Expression Regulation Developmental Cell Differentiation MESH: Transcription Factors Cell Biology Molecular biology MESH: Keratinocytes Cell biology Oxidative Stress medicine.anatomical_structure Animals Newborn Epidermal Cells Unfolded protein response Epidermis MESH: Epidermis Keratinocyte Transcription Factors MESH: Cells Cultured |
| Zdroj: | Biochemical and Biophysical Research Communications Biochemical and Biophysical Research Communications, 2008, 367 (2), pp.271-6. ⟨10.1016/j.bbrc.2007.12.115⟩ |
| ISSN: | 0006-291X 1090-2104 |
| DOI: | 10.1016/j.bbrc.2007.12.115 |
| Popis: | International audience; p63, a member of the p53 family, is transcribed from two different promoters giving rise to two different proteins: TAp63 that contains the N-terminal transactivation domain and DeltaN that lacks this domain. In this article we describe a new target gene Scotin induced by TAp63 during epithelial differentiation. This gene was previously isolated as a p53-inducible proapoptotic gene and the protein is located in the endoplasmic reticulum and in the nuclear membrane. Scotin expression is induced in response to endoplasmic reticulum (ER) stress in a p53 dependent or independent manner. We detected Scotin upregulation in primary keratinocyte cell lines committed to differentiate. In this paper we also show that Scotin is expressed in the supra basal layer of the epidermis in parallel with TAp63, but not DeltaNp63 expression. We conclude that Scotin is a new p63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect