Changes in Macular Pigment Optical Density among Pseudophakic Patients following Intake of a Lutein-Containing Supplement
| Autor: | Shigeki Machida, Rijo Hayashi, Shimmin Hayashi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Lutein medicine.medical_specialty medicine.medical_treatment Optical density Cataract Cellular and Molecular Neuroscience chemistry.chemical_compound Zeaxanthins Ophthalmology medicine Macular Pigment Humans In patient business.industry General Medicine Macular degeneration Cataract surgery medicine.disease eye diseases Sensory Systems chemistry Intraocular lenses Dietary Supplements Female sense organs business Pseudophakia |
| Zdroj: | Ophthalmic Research. 64:828-836 |
| ISSN: | 1423-0259 0030-3747 |
| DOI: | 10.1159/000517573 |
| Popis: | Introduction: Cataract surgery has been reported as a long-term risk of reduced macular pigment optical density (MPOD). This study investigated changes in MPOD in pseudophakic patients after lutein supplementation. Methods: Fifty-seven patients who had no ocular diseases and underwent cataract surgery with concurrent implantation of clear intraocular lenses were included. MPOD was measured before lutein supplementation and every week during 6 weeks of supplementation. Two additional measurements were conducted after the end of supplementation. Results: Compared with baseline, MPOD was increased after 1 week of supplementation (p < 0.01) and remained elevated after cessation of supplementation. After 3 weeks of supplementation, MPOD in females was higher than that in males (p < 0.05). Compared with patients at the highest quintile baseline MPOD, patients of both genders at the lowest quintile had significant increases after 6 weeks of supplementation (p < 0.05). Conclusion: MPOD increased after lutein supplementation in patients who had undergone cataract surgery. With the same amount of lutein supplementation, MPOD increased more in patients with low MPOD at baseline; it also increased more in females than in males. Lutein supplementation is presumed to support increased MPOD, which can reduce the risk of age-related macular degeneration, especially in females with low MPOD. |
| Databáze: | OpenAIRE |
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