The expression and distribution of neural salient serine/arginine-rich protein 1 in rat retina
| Autor: | Zheng-Yu Peng, Shu-Chen Lee, Xian-Hua Chen |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Retinal Ganglion Cells Retinal Bipolar Cells Arginine RNA Splicing Presynaptic Terminals Fluorescent Antibody Technique Cell Cycle Proteins Biology Retina Rats Sprague-Dawley Serine Antibody Specificity Bipolar neuron medicine Animals Axon Eye Proteins Neurons General Neuroscience Dentate gyrus Alternative splicing RNA-Binding Proteins Dendrites Immunohistochemistry Neoplasm Proteins Rats Repressor Proteins medicine.anatomical_structure nervous system RNA splicing sense organs Neuroscience |
| Zdroj: | NeuroReport. 18:1641-1644 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/wnr.0b013e3282f0b542 |
| Popis: | Neural salient serine/arginine-rich protein 1 (NSSR1) expression has been found in mouse cerebral neurons, cerebellar Purkinje cells, pyramidal neurons and granule cells of dentate gyrus and regulates the pre-mRNA splicing of genes important for neural functions. In this study, we demonstrated that NSSR1 is expressed in rat retina and extensively distributed in the outer and inner plexiform layers. Double staining experiments showed that NSSR1 distributed mainly in ON-type bipolar cells and localized in the dendrites, somata and axon terminals. The result suggests that NSSR1 may play important roles in retinal function, possibly via regulating the neural-specific alternative splicing of genes. |
| Databáze: | OpenAIRE |
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