Mixed oropharyngeal candidiasis due toCandida albicans and non-albicans Candida strains in HIV-infected patients
| Autor: | J V Martinez-Suarez, Fernando Laguna, González-López A, Fernando Dronda, J. L. Rodriguez-Tudela, Fernando Chaves, Alonso-Sanz M, Eulalia Valencia |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Gastroenterology Oropharyngeal Candidiasis Candidiasis Oral Internal medicine medicine Humans Candida albicans Fluconazole Mycosis Candida chemistry.chemical_classification AIDS-Related Opportunistic Infections biology Broth microdilution Pharyngeal Diseases General Medicine biology.organism_classification medicine.disease Corpus albicans Infectious Diseases chemistry Immunology Azole Female Ketoconazole medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 15:446-452 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/bf01691310 |
| Popis: | In order to determine the clinical significance of mixed oropharyngeal candidiasis (Candida albicans plus a non-albicans strain of Candida) in patients infected with HIV-1, a retrospective chart review was done in 12 HIV-1-infected patients with a clinical episode of oropharyngeal candidiasis, in whom a mixed culture of Candida albicans (found to be fluconazole-sensitive) plus a non-albicans species of Candida was obtained from their oral cavities. This group was compared with 26 HIV-positive patients (control group) with oropharyngeal candidiasis due to Candida albicans (found to be fluconazole-sensitive). Antifungal susceptibility testing was performed by a broth microdilution test with RPMI-2% glucose. A fungal strain was considered fluconazole-sensitive if its MIC was0.5 micrograms/ml. Both the study and control groups had similar clinical and demographic characteristics. All the patients were severely immunocompromised, with a mean CD4+ lymphocyte count of 63/mm3 (95% CI 41-84) and 80/mm3 (95% CI 25-135) in the study and control groups, respectively. In the study group, seven patients had Candida albicans and Candida krusei in their oral cavity, four had Candida albicans and Candida glabrata, and one had Candida albicans and Candida tropicalis. Antifungal therapy consisted of ketoconazole (5 patients in the study group, 14 in the control group) or fluconazole (7 patients in the study group, 12 in the control group); no statistically significant difference in clinical outcome was observed. Fungal strain persistence after therapy was frequently observed in both groups. It is concluded that non-albicans strains of Candida, less sensitive to azole drugs than their Candida albicans counterparts, are not clinically relevant in episodes of mixed oropharyngeal candidiasis in HIV-1-infected patients. |
| Databáze: | OpenAIRE |
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