Spanish multicenter study of surgical resection of pancreatic tumors infiltrating the celiac axis: does the type of pancreatectomy affect results?

Autor: J.M. Ramia, I. Lopez-Rojo, Y. Quijano, Fernando Pardo, Elena Martín-Pérez, Trinidad Villegas, Gerardo Blanco-Fernández, Luis Díez-Valladares, M.I. García-Domingo, Santiago López-Ben, Alvaro Gonzalez, M. Serradilla, F. Pereira, J. Herrera, Luis Sabater, E. De Vicente
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Cancer Research
medicine.medical_treatment
Distal pancreatectomy
Kaplan-Meier Estimate
Review
Gastroenterology
Body Mass Index
Postoperative Complications
PHAE
0302 clinical medicine
Celiac Artery
Embolization
Cancer
Pancreatoduodenectomy
General Medicine
Middle Aged
Treatment Outcome
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Pancreatectomy
Arterial
Female
Lymph
Pancreas
medicine.medical_specialty
Total pancreatectomy
Operative Time
Disease-Free Survival
03 medical and health sciences
Internal medicine
Pancreatic cancer
medicine
Humans
Neoplasm Invasiveness
Retrospective Studies
DP-CAR
business.industry
medicine.disease
Pancreatic Neoplasms
030104 developmental biology
Spain
Lymph Node Excision
Surgery
Observational study
Complication
business
Zdroj: CLINICAL & TRANSLATIONAL ONCOLOGY
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
ISSN: 1699-3055
1699-048X
Popis: BACKGROUND: Pancreatectomy plus celiac axis resection (CAR) is performed in patients with locally advanced pancreatic cancer. The morbidity rates are high, and no survival benefit has been confirmed. It is not known at present whether it is the type of pancreatectomy, or CAR itself, that is the reason for the high complication rates.; METHODS: Observational retrospective multicenter study.; INCLUSION CRITERIA: patient undergoing TP, PD or DP plus CAR for a pancreatic cancer.; RESULTS: Sixty-two patients who had undergone pancreatic cancer surgery (PD,TP or DP) plus CAR were studied. Group 1: 17 patients who underwent PD/TP-CAR (13TP/4PD); group 2: 45 patients who underwent DP-CAR. Groups were mostly homogeneous. Operating time was longer in the PD/TP group, while operative complications did not differ statistically in the two groups. The number of lymph nodes removed was higher in the PD/TP group (26.5 vs 17.3), and this group also had a higher positive node ratio (17.9% vs 7.6%). There were no statistical differences in total or disease-free survival between the two groups.; CONCLUSION: It seems that CAR, and not the type of pancreatectomy, influences morbidity and mortality in this type of surgery. International multicenter studies with larger numbers of patients are now needed to validate the data presented here.
Databáze: OpenAIRE
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