Nutrient Intake and Risk of Squamous Cell Carcinoma of the Esophagus: A Case-Control Study in Uruguay
| Autor: | Hugo Deneo-Pellegrini, Eduardo De Stefani, Alvaro L. Ronco, Giselle Acosta, Paolo Boffetta, María Mendilaharsu, Pelayo Correa |
|---|---|
| Přispěvatelé: | De Stefani, E., Ronco, A.L., Boffetta, P., Deneo-Pellegrini, H., Acosta, G., Correa, P., Mendilaharsu, M. |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Vitamin Cancer Research medicine.medical_specialty Esophageal Neoplasms Linoleic acid Medicine (miscellaneous) Physiology Diet Surveys Linoleic Acid chemistry.chemical_compound Lycopene Risk Factors Internal medicine Confidence Intervals Odds Ratio medicine Anticarcinogenic Agents Humans Esophagus Risk factor Aged Aged 80 and over Nutrition and Dietetics business.industry Esophageal disease Case-control study Vitamins Odds ratio Middle Aged medicine.disease Carotenoids Confidence interval Diet medicine.anatomical_structure Endocrinology Oncology chemistry Case-Control Studies Carcinoma Squamous Cell Uruguay Female business Squamous cell carcinoma of the esophagus |
| Zdroj: | Nutrition and Cancer. 56:149-157 |
| ISSN: | 1532-7914 0163-5581 |
| DOI: | 10.1207/s15327914nc5602_5 |
| Popis: | In 1996-2004 a case-control study on nutrient intake, dietary constituents and risk of squamous cell carcinoma of the esophagus was conducted in Montevideo, Uruguay. In fact, Uruguay, and especially its northern provinces, which border Brazil, are high-risk areas. The study included 234 cases and 936 controls. The controls were hospitalized patients with non-neoplastic disease, which was not related to tobacco smoking and alcohol drinking, and without recent changes in their diets. Controls were frequency matched to cases on age (10-yr intervals), sex, and residence (Montevideo and other provinces). Dietary constituents were energy adjusted using the residuals method and then categorized in quartiles according to the distribution of the controls. The final model included linoleic acid, lycopene, a-carotene, ß-cryptoxanthin, vitamin A, monounsaturated fat, total carbohydrates, ß-carotene, and folate. The odds ratio (OR) for high intake of linoleic acid was 1.4 (95% confidence interval, CI = 1.2-1.6), whereas lycopene displayed a strong protective effect (OR = 0.7; 95% CI = O.6-0.9). The possible role of these and other dietary constituents in esophageal carcinogenesis is discussed. Copyright © 2006, Lawrence Erlbaum Associates, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|