Hepatitis B virus reactivation in HBsAg-negative patients is associated with emergence of viral strains with mutated HBsAg and reverse transcriptase
| Autor: | Anne Motte, Catherine Tamalet, René Gerolami, D. Botta-Fridlund, Aude Charbonnier, Patrick Borentain, Julie Bertrand, Diane Coso, Jacques Serratrice, Isabelle Portal, Thérèse Aurran-Schleinitz, Anne-Marie Stoppa, Fabrice Barlesi, Mélanie Serrero, Christian Chabannon, Philippe Colson |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Hepatitis B virus HBsAg Hepatitis B virus DNA polymerase Antineoplastic Agents Biology medicine.disease_cause Hepatitis B virus PRE beta Serology Neoplasms Virology HBV therapy medicine Chemotherapy Humans HBV-DNA detection Aged Hepatitis B virus reactivation Hepatitis B Surface Antigens Nucleoside analogue virus diseases RNA-Directed DNA Polymerase Middle Aged Resistance mutation digestive system diseases Reverse transcriptase Female Mutant Proteins Virus Activation medicine.drug |
| Zdroj: | Virology. 484:354-363 |
| ISSN: | 0042-6822 |
| Popis: | Background/aims Virological factors associated with hepatitis B virus reactivation (HBV-R), following chemotherapy for cancer in hepatitis B surface antigen (HBsAg)-negative patients, are not well known. Materials and methods HBV strains from 16 patients presenting HBV-R following chemotherapy were studied and compared to those obtained from 51 HBV chronically-infected patients. Results HBsAg variability was significantly increased within the major hydrophilic region, the a determinant and the C-terminal region. Amino acid substitutions were more frequently found in HBV-R patients as compared to controls at 17 and 11 positions within HBsAg and HBV-RT, respectively. This resulted in atypical serological testing in 56% of patients and detection of resistance mutation to nucleoside analogs in 12.5%. Conclusion HBsAg and HBV-RT mutations are frequently encountered in patients with HBV-R, resulting in atypical serological testing and emergence of HBV strains resistant to nucleos(t)ides analogs. |
| Databáze: | OpenAIRE |
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