The Relationship Between Menopause and Metabolic Syndrome: Experimental and Bioinformatics Analysis
| Autor: | Abir Jaballah, Salima Ferchichi, Yosra Hasni, Ismael Soltani, A. Dandana, Abdelhedi Miled, Wael Bahia |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Parathyroid hormone Type 2 diabetes Biology Biochemistry 03 medical and health sciences Prolactin signaling pathway 0302 clinical medicine Risk Factors Internal medicine Genetics medicine Humans Lipid localization Molecular Biology Ecology Evolution Behavior and Systematics Aged Metabolic Syndrome Computational Biology General Medicine Middle Aged medicine.disease Human genetics Postmenopause Menopause 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Female Metabolic syndrome Hormone |
| Zdroj: | Biochemical Genetics. 59:1558-1581 |
| ISSN: | 1573-4927 0006-2928 |
| DOI: | 10.1007/s10528-021-10066-7 |
| Popis: | Menopausal hormonal changes have been associated with the emergence of the metabolic syndrome (MetS) and its consequences such as type 2 diabetes (T2D) and cardiovascular diseases (CVD). The common gene signature and the associated signaling pathways of MetS, T2D, CVD and menopause status have not been widely studied. We analyzed a total of 314 women aged between 35 and 75 years. The sample was divided into two groups: Group I, including women in the premenopausal period and Group II, comprising women in the post-menopausal period. The presence of MetS and its components were evaluated, as well as occurrence of T2D and CVD in both groups. We also exploited the translational bioinformatics approach to choose the common gene signatures for MetS, T2D, CVD and the menopause status. The frequency of the MetS was significantly higher in postmenopausal women than in premenopausal ones (67.1 vs. 27.2%, p |
| Databáze: | OpenAIRE |
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