Prenatal developmental toxicity study of ethyltertiary-butyl ether in rats
| Autor: | Takako Muroi, Kotaro Furukawa, Saori Takakura, Katsumi Miyata, Yuji Kusune, Satsuki Hoshuyama, Sunao Aso, Shozo Ajimi |
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| Rok vydání: | 2013 |
| Předmět: |
Male
No-observed-adverse-effect level Health Toxicology and Mutagenesis medicine.medical_treatment Developmental toxicity Physiology Toxicology Body weight Statistics Nonparametric Fetal Development Rats Sprague-Dawley Eating Pregnancy medicine Animals Caesarean section reproductive and urinary physiology Pharmacology No-Observed-Adverse-Effect Level Fetus Chemical Health and Safety Dose-Response Relationship Drug Chemistry Body Weight Public Health Environmental and Occupational Health Embryo General Medicine medicine.disease Rats Ethyl Ethers Dose–response relationship Anesthesia embryonic structures Female |
| Zdroj: | Drug and Chemical Toxicology. 37:17-24 |
| ISSN: | 1525-6014 0148-0545 |
| DOI: | 10.3109/01480545.2013.806527 |
| Popis: | Ethyl tertiary-butyl ether (ETBE) is commonly used as an oxygenated gasoline additive. In this study, we evaluated its developmental toxicity in rats. ETBE was administered by gavage to 21 or 22 pregnant female Sprague-Dawley rats per group at dose levels of 0, 100, 300 and 1000 mg/kg/day from days 5 through 19 postcoitum to assess its effects on pregnant animals and their embryos and fetuses applied to the OECD testing guideline (no. 414) correspondingly. There were no toxicological effects attributable to ETBE regarding clinical signs, body weight, food intake, necropsy or examination at caesarean section in pregnant animals. There were also no toxicological effects on external, visceral and skeletal examinations of embryos and fetuses. These results indicate that, under the conditions of this study, ETBE had no toxicological effects on pregnant rats or their embryos and fetuses and that the no observed adverse effect level was 1000 mg/kg/day both for pregnant rats and their embryos and fetuses. |
| Databáze: | OpenAIRE |
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