Expression profile of interferon stimulated genes in central nervous system of mice infected with dengue virus Type-1
| Autor: | Nusara Satproedprai, Daniela Parada Pavoni, Silvio M. Zanata, Juliano Bordignon, Claudia Nunes Duarte dos Santos, Ana Luiza Pamplona Mosimann, Paul Fawcett, Christian Probst, Gregory A. Buck, Marco Aurélio Krieger, Lucia de Noronha, Vanessa Stella |
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| Jazyk: | angličtina |
| Předmět: |
Microarray
Transcription Genetic viruses Antigen presentation Disease Dengue virus Biology medicine.disease_cause Dengue fever Dengue Mice Interferon Virology medicine Animals Gene Expression Profiling virus diseases medicine.disease Viral replication Central nervous system Immunology Neuropathogenesis Interferons Software medicine.drug |
| Zdroj: | Virology. (2):319-329 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2008.04.033 |
| Popis: | Dengue virus (DENV) infection can cause a self-limiting disease (dengue fever) or a more severe clinical presentation known as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Furthermore, data from recent dengue epidemics in Brazil indicate that the neurological manifestations are becoming more prevalent. However, the neuropathogenesis of dengue are not well understood. The balance between viral replication efficiency and innate immunity — in opposition during the early stages of infection — determines the clinical outcome of DENV infection. In this study, we investigated the effects of DENV infection on the transcription profile of the central nervous system (CNS) of mice. We observed in infected mice the up-regulation of 151 genes possibly involved in neuropathogenesis of dengue. Conversely, they may have a protective effect. Ingenuity Systems software analysis demonstrated, that the main pathways modulated by DENV infection in the mouse CNS are involved in interferon signaling and antigen presentation. |
| Databáze: | OpenAIRE |
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