Blood Glucose Self-Monitoring with a Long-Term Subconjunctival Glucose Sensor
| Autor: | Monika Knuth, Katharina Nikolaus, Gerd U. Auffarth, Frank Küster, Roland Krivánek, Achim Josef Müller, Christoph Hasslacher |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Biomedical Engineering Bioengineering Biosensing Techniques Clinical study Interstitial fluid Blood Glucose Self-Monitoring Ophthalmology Diabetes mellitus Internal Medicine Diabetes Mellitus Medicine Humans Monitoring Physiologic business.industry Monitoring system Middle Aged medicine.disease Biocompatible material Surgery Surface coating Mini implants Feasibility Studies Female business Conjunctiva Research Article |
| Popis: | Background: To evaluate the feasibility of an implantable subconjunctival glucose monitoring system (SGMS) for long-term glucose monitoring, we investigated the in vivo performance of the system. Method: The SGMS consists of an implantable ocular mini implant (OMI) and a handheld fluorescence photometer. A clinical study was performed on 47 diabetes patients split into two cohorts. Two different types of OMI were used, with and without a biocompatible surface coating. Duration of the study was 1 year. Correlation between capillary blood glucose and SGMS-derived interstitial fluid glucose was investigated during the first 6 months of the study. Results: Both OMI types were tolerated well in the eyes of the patients. At the beginning of the study, the SGMS of both cohorts revealed a high accuracy with mean absolute relative difference (MARD) values of 7–12%. The performance of the uncoated OMIs deteriorated within 3 months of wearing time, exhibiting a MARD value of 20%. The performance of the surface-coated OMIs was preserved longer. Glucose correlation measurement with reasonable results (MARD of 14%) could be performed for up to 6 months of wear. Conclusions: The biocompatible surface coating on the OMIs enabled a longer duration of action of up to 6 months compared with 3 months for uncoated implants in a clinical trial. |
| Databáze: | OpenAIRE |
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