Effects of Chronic Arachidonate on Blood Pressure of Spontaneously Hypertensive Rats
| Autor: | D. Ezra, Mohamed A. Bayorh, Giora Feuerstein, Irwin J. Kopin, J. D. Lazar, Zofia Zukowska-Grojec |
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| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System Time Factors Indomethacin Hemodynamics Blood Pressure Pressoreceptors Arachidonic Acids Spinal cord stimulation Norepinephrine (medication) Norepinephrine chemistry.chemical_compound Catecholamines Internal medicine Internal Medicine medicine Animals Arachidonic Acid biology business.industry Angiotensin II Body Weight Rats Inbred Strains Rats Peripheral Blood Vessel Endocrinology Blood pressure chemistry Hypertension biology.protein Vascular Resistance Arachidonic acid Cyclooxygenase business medicine.drug |
| Zdroj: | Clinical and Experimental Hypertension. Part A: Theory and Practice. 5:1485-1499 |
| ISSN: | 0730-0077 |
| DOI: | 10.3109/10641968309069506 |
| Popis: | Three weeks of treatment with arachidonic acid (250 mg/kg/day, s.c.) produced an antihypertensive effect in 16 week-old spontaneously hypertensive rats (SHR) as compared with vehicle treated rats. Indomethacin (4 mg/kg, s.c. B.I.D.), given concurrently with arachidonate, abolished the antihypertensive effect. Plasma catecholamines were not altered by the arachidonate treatment, but blood pressure increments after spinal cord stimulation or after intravenous administration of norepinephrine and angiotensin II in the pithed rat were diminished. Increments in plasma catecholamines in response to spinal cord stimulation were similar in both groups of pithed rats. These data demonstrate the antihypertensive effect of arachidonic acid in SHR with established hypertension. This beneficial effect seems to be mediated through cyclooxygenase metabolites, and might be related to reduced responsiveness of peripheral blood vessels to pressor stimuli. |
| Databáze: | OpenAIRE |
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