Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications

Autor: Catarina F. Marques, Rui L. Reis, Tiago H. Silva, J. Miguel Oliveira, Sandra Pina, F. Raquel Maia, Viviana P. Ribeiro
Přispěvatelé: Universidade do Minho
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Engineering
Scaffold
biopolymers
Review
02 engineering and technology
01 natural sciences
Regenerative medicine
lcsh:Technology
porous structures
Biopolymers
Tissue engineering
General Materials Science
lcsh:QC120-168.85
Decellularization
Hydrogels
Porous structures
021001 nanoscience & nanotechnology
3. Good health
scaffolds
tissue engineering
Self-healing hydrogels
0210 nano-technology
bioprinting
lcsh:TK1-9971
biomaterials
regenerative medicine
inorganic materials
010402 general chemistry
Biomaterials
Biological property
lcsh:Microscopy
hydrogels
Scaffolds
Science & Technology
lcsh:QH201-278.5
business.industry
lcsh:T
Regeneration (biology)
Bioprinting
Inorganic Materials
0104 chemical sciences
lcsh:TA1-2040
Inorganic materials
lcsh:Descriptive and experimental mechanics
lcsh:Electrical engineering. Electronics. Nuclear engineering
business
lcsh:Engineering (General). Civil engineering (General)
Biomedical engineering
Zdroj: Materials, Vol 12, Iss 11, p 1824 (2019)
Materials
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ISSN: 1996-1944
Popis: During the past two decades, tissue engineering and the regenerative medicine field have invested in the regeneration and reconstruction of pathologically altered tissues, such as cartilage, bone, skin, heart valves, nerves and tendons, and many others. The 3D structured scaffolds and hydrogels alone or combined with bioactive molecules or genes and cells are able to guide the development of functional engineered tissues, and provide mechanical support during in vivo implantation. Naturally derived and synthetic polymers, bioresorbable inorganic materials, and respective hybrids, and decellularized tissue have been considered as scaffolding biomaterials, owing to their boosted structural, mechanical, and biological properties. A diversity of biomaterials, current treatment strategies, and emergent technologies used for 3D scaffolds and hydrogel processing, and the tissue-specific considerations for scaffolding for Tissue engineering (TE) purposes are herein highlighted and discussed in depth. The newest procedures focusing on the 3D behavior and multi-cellular interactions of native tissues for further use for in vitro model processing are also outlined. Completed and ongoing preclinical research trials for TE applications using scaffolds and hydrogels, challenges, and future prospects of research in the regenerative medicine field are also presented.
This research was funded by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) (NORTE-01-0145-FEDER-000023) and by the Portuguese Foundation for Science and Technology ((M-ERA-NET/0022/2016), Transitional Rule DL 57/2016 (CTTI-57/18-I3BS(5)), and (IF/01285/2015)).
Databáze: OpenAIRE
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