Less Limb Muscle Involvement in Myositis Patients with Anti-Mitochondrial Antibodies
| Autor: | Yoshihisa Ohtsuka, Kenji Sekiguchi, Tsuneyoshi Seki, Hisatomo Kowa, Takeshi Uenaka, Fumio Kanda, Tatsushi Toda |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty 030204 cardiovascular system & hematology Polymyositis Mitochondrial Proteins 03 medical and health sciences 0302 clinical medicine Atrophy medicine Humans Muscle Skeletal Myositis Autoantibodies Retrospective Studies Muscle biopsy Muscle Weakness medicine.diagnostic_test business.industry Autoantibody Middle Aged medicine.disease Muscle atrophy Neurology Biomarker (medicine) Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Biomarkers Anti-mitochondrial antibody |
| Zdroj: | European neurology. 78(5-6) |
| ISSN: | 1421-9913 |
| Popis: | Recent studies have revealed the clinical, histological, and pathophysiological characteristics in a group of inflammatory myopathies with selected autoantibodies. We retrospectively compared the clinical manifestations and histological features between 8 anti-mitochondrial (anti-M2) antibody-positive and 33 antibody-negative patients. Patients with anti-M2 antibodies have been previously reported to have delayed diagnostic confirmation and frequent cardiopulmonary complications in comparison to those without the antibodies. In our study, clinical characteristics in patients with the antibodies were as follows: lesser degree of limb muscle weakness and atrophy as well as lymphocytic infiltration in muscle biopsy specimens, and frequent paravertebral muscle atrophy. Anti-M2 antibody appeared to be a biomarker related to not only cardiopulmonary complications, but also characteristic distributions of affected muscles. |
| Databáze: | OpenAIRE |
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