Stem cell differentiation trajectories in Hydra resolved at single-cell resolution
| Autor: | Abby S. Primack, Celina E. Juliano, Jack F. Cazet, Stefan Siebert, Jeffrey A. Farrell, Yashodara L. Abeykoon, Christine E. Schnitzler |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
General Science & Technology
Hydra 1.1 Normal biological development and functioning Cellular differentiation Cell Computational biology Biology Regenerative Medicine Article Transcriptome 03 medical and health sciences 0302 clinical medicine Single-cell analysis Underpinning research Genetics medicine Animals Regeneration Cell Lineage Gene 030304 developmental biology 0303 health sciences Multidisciplinary Stem Cells Resolution (electron density) Cell Differentiation Stem Cell Research medicine.anatomical_structure Evolutionary biology Lernaean Hydra Stem Cell Research - Nonembryonic - Non-Human Generic health relevance Stem cell Single-Cell Analysis Function (biology) 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Science (New York, N.Y.), vol 365, iss 6451 |
| Popis: | Mapping Hydra development cell by cell Hydra continually renews all cells in its body using three stem cell populations. This feature of Hydra allowed Siebert et al. to identify the transcriptional signatures of stem cells, progenitors, and terminally differentiated cells using single-cell RNA sequencing of adult Hydra (see the Perspective by Reddien). From these data, they built differentiation trajectories for all cell lineages, identified gene modules expressed along these trajectories, and identified putative regulators of genes within these modules. In addition, they identified candidate markers for elusive cell populations (such as multipotent stem cells and germline stem cells) and built a molecular map of the nervous system. Science , this issue p. eaav9314 ; see also p. 314 |
| Databáze: | OpenAIRE |
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