Increased levels of mannan-binding lectin in type 1 diabetic patients with incipient and overt nephropathy
| Autor: | Torben Hansen, Lise Tarnow, J. Fagerudd, Allan Flyvbjerg, Anna-Maija Teppo, Markku Saraheimo, Pertti Ebeling, Carol Forsblom, P.-H. Groop, Steffen Thiel, K. Pettersson-Fernholm |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism chemical and pharmacologic phenomena Mannose-Binding Lectin Body Mass Index Nephropathy Diabetic nephropathy Insulin resistance Internal medicine Diabetes mellitus Internal Medicine medicine Albuminuria Body Size Humans Diabetic Nephropathies Age of Onset Mannan-binding lectin Type 1 diabetes business.industry bacterial infections and mycoses medicine.disease Lipids Diabetes Mellitus Type 1 Endocrinology ACE inhibitor Biological Markers Female Microalbuminuria business Biomarkers Glomerular Filtration Rate medicine.drug |
| Zdroj: | Saraheimo, M, Forsblom, C, Hansen, T K, Teppo, A-M, Fagerudd, J, Pettersson-Fernholm, K, Thiel, S, Tarnow, L, Ebeling, P, Flyvbjerg, A, Groop, P-H & FinnDiane Study Group 2005, ' Increased levels of mannan-binding lectin in type 1 diabetic patients with incipient and overt nephropathy ', Diabetologia, vol. 48, no. 1, pp. 198-202 . https://doi.org/10.1007/s00125-004-1594-1 Saraheimo, M, Forsblom, C, Hansen, T K, Teppo, A M, Fagerudd, J, Pettersson-Fernholm, K, Thiel, S, Tarnow, L, Ebeling, P, Flyvbjerg, A & Groop, P H 2005, ' Increased levels of mannan-binding lectin in type 1 diabetic patients with incipient and overt nephropathy ', Diabetologia, vol. 48, pp. 198-202 . |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/s00125-004-1594-1 |
| Popis: | Diabetic nephropathy is associated with insulin resistance, and low-grade inflammation and activation of the complement system may contribute to this cascade. Mannan-binding lectin (MBL) activates the complement system, and elevated MBL concentrations have been observed in normoalbuminuric type 1 diabetic patients. The aim of this study was to assess whether MBL is associated with diabetic nephropathy in type 1 diabetes, and whether there is an association between MBL and low-grade inflammatory markers or insulin resistance.A total of 191 type 1 diabetic patients from the Finnish Diabetic Nephropathy Study were divided into three groups based upon their AER. Patients with normal AER (n=67) did not take antihypertensive medication, while patients with microalbuminuria (n=62) or macroalbuminuria (n=62) were all treated with an ACE inhibitor. As a measure of insulin sensitivity we used estimated glucose disposal rate. MBL was measured by an immunofluorometric assay, C-reactive protein by a radioimmunoassay and IL-6 by high-sensitivity enzyme immunoassay.Patients with normal AER (median [interquartile range]: 1,154 microg/l [180-2,202 microg/l]) had lower levels of MBL than patients with microalbuminuria (1,713 microg/l [724-2,760 microg/l]; p=0.029) or macroalbuminuria (1,648 microg/l [568-3,394 microg/l]; p=0.019). There was a significant correlation between MBL and estimated glucose disposal rate, but not between MBL and C-reactive protein or IL-6 levels in univariate analysis. However, in a multiple regression analysis, HbA1c was the single variable independently associated with MBL (beta+/-SEM: 0.26+/-0.08; p=0.003).MBL concentrations are increased in type 1 diabetic patients with diabetic nephropathy. MBL was not associated with low-grade inflammatory markers. |
| Databáze: | OpenAIRE |
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