Associations of body mass index and waist circumference with risk of Guillain-Barré syndrome in women and men: A prospective analysis of three cohort studies

Autor: Beverly J Wolpert, Jorge E. Chavarro, Ming Ding, André O. Markon
Rok vydání: 2020
Předmět:
Male
Physiology
Epidemiology
Autoimmune diseases
Guillain-Barre syndrome
Clinical immunology
030204 cardiovascular system & hematology
Overweight
Body Mass Index
0302 clinical medicine
Risk Factors
Medicine and Health Sciences
Public and Occupational Health
Prospective Studies
030212 general & internal medicine
Prospective cohort study
Multidisciplinary
Obstetrics
Cancer Risk Factors
Hazard ratio
Middle Aged
Physiological Parameters
Oncology
Medicine
Female
Waist Circumference
medicine.symptom
Research Article
Cohort study
Adult
medicine.medical_specialty
Waist
Science
Immunology
03 medical and health sciences
medicine
Humans
Obesity
Proportional Hazards Models
Nutrition
Waist-Hip Ratio
Proportional hazards model
business.industry
Body Weight
Biology and Life Sciences
Physical Activity
medicine.disease
Diet
Medical Risk Factors
Clinical medicine
business
Body mass index
Follow-Up Studies
Zdroj: PLoS ONE, Vol 15, Iss 12, p e0239099 (2020)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0239099
Popis: Background The association of body mass index (BMI) and waist circumference (WC) with risk of Guillain-Barré syndrome (GBS) has been inconsistent in previous studies. Methods We examined the associations of BMI and WC in relation to risk of GBS among 252,980 participants from the Nurses’ Health Study (NHS), NHS-II, and the Health Professional Follow-up Study (HPFS). BMI and WC were assessed by self-reported questionnaire, and GBS cases were self-reported. Results We documented 328 incident GBS cases during a total of 5,422,788 person years of follow-up. Compared to participants with BMI2, the multivariate pooled hazard ratio (HR) of GBS was 1.34 (95% CI: 1.04, 1.73) for overweight participants (25kg/m2≤BMI2), and 1.68 (95% CI: 1.21, 2.35) for obese participants (BMI≥30 kg/m2) (P for trend = 0.001). Compared to participants with normal WC (2 in comparison to participants with normal WC and BMI2. Conclusion These data from large cohorts showed that higher BMI and WC jointly were associated with higher risk of GBS. Our study highlighted the importance of maintaining a normal body weight and waist circumference in prevention of GBS.
Databáze: OpenAIRE
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