Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors
| Autor: | John Skoumas, N Galiatsatos, Christos Pitsavos, George Lazaros, Constantina Masoura, Panagiotis Xydis, Aggelos Papanikolaou, Kyriakos Dimitriadis, Konstantinos Tsioufis, Konstantinos Konstantinou, Matina Kouvari, John Varlas, M. Kambaxis, Christina Chrysohoou, Marina Zaromytidou, Christodoulos Stefanadis |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty obesity primary prevention lcsh:TX341-641 030209 endocrinology & metabolism heart disease 030204 cardiovascular system & hematology Article Body Mass Index 03 medical and health sciences Sex Factors Vascular Stiffness 0302 clinical medicine Insulin resistance Internal medicine lean mass Epidemiology medicine gender Humans Prospective Studies Muscle Skeletal Aged Proportional Hazards Models body composition Nutrition and Dietetics Greece business.industry Proportional hazards model Hazard ratio aging Middle Aged medicine.disease Obesity Confidence interval Cardiovascular Diseases Lean body mass Female women Insulin Resistance business lcsh:Nutrition. Foods and food supply Body mass index Food Science |
| Zdroj: | Nutrients Volume 12 Issue 11 Nutrients, Vol 12, Iss 3293, p 3293 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12113293 |
| Popis: | The sex-specific effect of skeletal muscle mass (SMM) index (SMI) on 4-year first fatal/non-fatal cardiovascular disease (CVD) event in free-of-disease individuals was examined. In 2009, n = 1411 inhabitants (mean age = 64(12)) from Ikaria were selected. Follow-up was performed in 2013. SMI was created to reflect SMM through appendicular skeletal muscle mass (indirectly calculated through formulas) divided by body mass index (BMI). Fifteen and six tenths percent of participants exhibited CVD (19.8% in men/12% in women, p = 0.002). Significant U-shape trends were observed in participants > 65 years old and women irrespective to age confirmed through multi-adjusted Cox regression analysis in age > 65 years, Hazard Ratio (HR)(2nd vs. 1st SMI tertile) = 0.80, 95% Confidence Interval (95%CI) (0.45, 0.96) and in women HR(2nd vs. 1st SMI tertile) = 0.71, 95% CI (0.33, 0.95), while, as for the 3rd SMI tertile, no significant trends were observed. Mediation analysis revealed that mediators of the aforementioned associations in men were the arterial distensibility and total testosterone, while, in women, inflammation, insulin resistance, and arterial distensibility. High SMM accompanied by obesity may not guarantee lower CVD risk. Specific cardiometabolic factors seem to explain this need for balance between lean and fat mass. |
| Databáze: | OpenAIRE |
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