Signaling pathways engaged by NK cell receptors: double concerto for activating receptors, inhibitory receptors and NK cells
| Autor: | M Bléry, F Vély, Eric Vivier, E Tomasello |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cytotoxicity
Immunologic Lymphokine-activated killer cell biology T cell Immunology Models Immunological Immune receptor Molecular biology Cell biology Killer Cells Natural Interleukin 21 medicine.anatomical_structure MHC class I biology.protein medicine Immunology and Allergy Receptors Immunologic Signal transduction Antigen-presenting cell Receptor Immunosuppressive Agents Signal Transduction |
| Zdroj: | Seminars in Immunology. 12:139-147 |
| ISSN: | 1044-5323 |
| DOI: | 10.1006/smim.2000.0216 |
| Popis: | Despite the absence of antigen-specific receptors at their surface, NK cells can selectively eliminate virus-infected cells, tumor cells and allogenic cells. A dynamic and precisely coordinated balance between activating and inhibitory receptors governs NK cell activation programs. Multiple activating and inhibitory NK cell surface molecules have been described, a group of them acting as receptors for MHC class I molecules. In spite of their heterogeneity, activating NK cell receptors present remarkable structural and functional homologies with T cell- and B cell-antigen receptors. Inhibitory NK cell receptors operate at early stages of activating cascades by recruiting protein tyrosine phosphatases via intra- cytoplasmic motifs (ITIM), a strategy which is widely conserved in hematopoietic and non-hematopoietic cells. |
| Databáze: | OpenAIRE |
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