Application of Proteomic Tools in Modern Nanotechnological Approaches Towards Effective Management of Neurodegenerative Disorders
| Autor: | Ashraf Ali, Siew Hua Gan, Ghulam Md Ashraf, Ishfaq Ahmed Sheikh, Adel M. Abuzenadah, Mohammad Amjad Kamal, Ghazi A. Damanhouri, Zeenat Mirza |
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| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
Proteomics Clinical Biochemistry Disease mechanisms Neurodegeneration Age Factors Genomics Effective management Neurodegenerative Diseases Computational biology Disease Biology Bioinformatics medicine.disease Metabolomics Drug Delivery Systems Drug Design medicine Animals Humans Nanoparticles Nanotechnology Epigenomics |
| Zdroj: | Current drug metabolism. 16(5) |
| ISSN: | 1875-5453 |
| Popis: | Neurodegeneration is the progressive loss of structure or function of neurons leading to neuronal death, usually associated with ageing. Some of the common neurodegenerative disorders include Alzheimer’s disease, Parkinson’s disease, Creutzfeldt-Jakob disease, and Huntington’s disease. Due to recent advancements in highthroughput technologies in various disciplines such as genomics, epigenomics, metabolomics and proteomics, there has been a great demand for detection of specific macromolecules such as hormones, drug residues, miRNA, DNA, antibodies, peptides, proteins, pathogens and xenobiotics at nano-level concentrations for in-depth understanding of disease mechanisms as well as for the development of new therapeutic strategies. The present review focuses on the management of agerelated neurodegenerative disorders using proteomics and nanotechnological approaches. In addition, this review also highlights the metabolism and disposition of nano-drugs and nano-enabled drug delivery in neurodegenerative disorders. |
| Databáze: | OpenAIRE |
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