Relationship between weakness and phase angle in advanced cancer patients with fatigue
| Autor: | P. Cresta Morgado, N. López Delgado, Octavio Casbarien, M. Perman, R. Giglio, Alfredo Navigante |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Weakness medicine.medical_specialty Lung Neoplasms Population Body Mass Index Carcinoma Non-Small-Cell Lung Weight Loss Healthy volunteers Electric Impedance Humans Medicine Muscle Strength Prospective Studies education Prospective cohort study Fatigue Aged Aged 80 and over education.field_of_study Hand Strength Squamous Cell Carcinoma of Head and Neck business.industry Phase angle Cancer Middle Aged medicine.disease Advanced cancer Healthy Volunteers Oncology Head and Neck Neoplasms Bioimpedance Analysis Carcinoma Squamous Cell Physical therapy Female medicine.symptom business |
| Zdroj: | Supportive Care in Cancer. 21:1685-1690 |
| ISSN: | 1433-7339 0941-4355 |
| Popis: | This study aims to determine the relationship between weakness and bioimpedance analysis (BIA)-derived phase angle in a population of untreated cancer patients with fatigue.We prospectively evaluated 41 treatment-naive cancer patients of several origins that presented with performance status 1-2, weight loss5% in the last 6 months, and Fatigue Numeral Scale score4. Weakness was considered a physical component of the multidimensional fatigue syndrome and was evaluated through several parameters utilizing hand grip strength technique by dinamometry. The same assessment was also performed on a healthy control population (n = 20). BIA-derived phase angle was also determined by BIA.Compared to healthy controls, cancer patients exhibited significant differences in all the parameters: median fatigue was 6 (range 5-9), evaluated maximal strength mean was 27 ± 10.71 vs. 42 ± 10.74 kg (p 0.0001 for patients vs. control, respectively), and muscle strength difference (max-min muscle strength) was also statistically different (p 0.0001). We also determined parameter associations within the patient population. We found statistical significant correlations between median phase angle score and endurance muscle with percentage of weight loss (r = 0.43, p = 0.03) for head and neck cancer patients, and in non-small cell lung cancer patients, grip work correlated significantly with normal or decreased phase angle (r = 0.85), p = 0.006 (Spearman Rank Correlation).Weakness could be correlated with normal or decreased phase angle in a population with ambulatory advanced cancer with fatigue naive of treatment. We also found a significant relationship between median phase angle score and endurance muscle with percentage of weight loss in the subpopulation of patients with head and neck carcinoma. |
| Databáze: | OpenAIRE |
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