No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents
| Autor: | Mai Ono, Shota Nishitani, Kazuyuki Shinohara, Akemi Tomoda, Takashi X. Fujisawa, Junko Kawatani, Naomi Matsuura, Daiki Toyohisa |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Genotype Locus (genetics) Social Environment Logistic regression Life Change Events Asian People Japan medicine Humans Genetic Predisposition to Disease Gene–environment interaction Allele Child Psychiatry Gene Alleles Genetic Association Studies Serotonin transporter Serotonin Plasma Membrane Transport Proteins Depressive Disorder biology Social environment Gene-by-environment (G × E) interaction Child depression Serotonin transporter gene (5-HTTLPR) Polymorphism Psychiatry and Mental health Early adversity biology.protein Female Gene-Environment Interaction Psychology Research Article |
| Zdroj: | BMC Psychiatry |
| ISSN: | 1471-244X |
| DOI: | 10.1186/1471-244x-13-134 |
| Popis: | Background: Identification of gene × environment interactions (G × E) for depression is a crucial step in ascertaining the mechanisms underpinning the disorder. Earlier studies have indicated strong genetic influences and numerous environmental risk factors. In relation to childhood and adolescent depression, evidence is accumulating that the quality of the parental environment is associated with serotonin biology in children. We hypothesized that maternal depression is a crucial environmental risk factor associated with serotonin-regulating genes.Methods: This study was designed to ascertain the G × E interaction for diagnosis of depression in a Japanese pediatric sample. DNA samples from 55 pediatric patients with depression and 58 healthy schoolchildren were genotyped for the 5-HTT (2 short (S) alleles at the 5-HTT locus) promoter serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphism. We examined whether an adverse parental environment, operationalized as the mother's history of recurrent major depressive disorder, interacts with 5-HTTLPR polymorphism to predict patients' depression symptoms.Results: Binary logistic regression analyses revealed that maternal depression (adversity), gender, and FSIQ significantly affect the diagnosis of depression among children and adolescents. However, no main effect was found for adversity or genotype. Results of multivariable logistic regression analyses using stepwise procedure have elicited some models with a good fit index, which also suggests no interaction between 5-HTTLPR and adversity on depression.Conclusions: To assess G × E interaction, data obtained from children and adolescents who had been carefully diagnosed categorically and data from age-matched controls were analyzed using logistic regression. Despite an equivocal interaction effect, adversity and gender showed significant main effects. BMC Psychiatry, 13(1), Article number 134; 2013 |
| Databáze: | OpenAIRE |
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