Reactions of Subcutaneous Connective Tissue to Mineral Trioxide Aggregate, Biodentine®, and a Newly Developed BioACTIVE Base/Liner
| Autor: | Cafer Ataş, Nazmiye Dönmez, Ceren Canbey Göret, Barış Karabulut, Özlem Kuzu |
|---|---|
| Přispěvatelé: | DÖNMEZ, NAZMİYE |
| Rok vydání: | 2020 |
| Předmět: |
Male
Mineral trioxide aggregate Pathology medicine.medical_specialty Necrosis Subcutaneous connective tissue Article Subject Connective tissue Biocompatible Materials Inflammation 02 engineering and technology BioACTIVE Rats Sprague-Dawley Root Canal Filling Materials 03 medical and health sciences Calcification Physiologic 0302 clinical medicine Dystrophic calcification Materials Testing medicine Animals Aluminum Compounds Instrumentation Microscopy Chemistry Silicates QH201-278.5 Oxides 030206 dentistry Calcium Compounds 021001 nanoscience & nanotechnology medicine.disease Atomic and Molecular Physics and Optics Rats Pulp capping Drug Combinations medicine.anatomical_structure Connective Tissue medicine.symptom 0210 nano-technology Research Article Calcification |
| Zdroj: | Scanning, Vol 2020 (2020) Scanning |
| Popis: | Aim. There is an increasing interest in the application of BioACTIVE materials to achieve hard tissue formation and maintain pulp vitality. Mineral trioxide aggregate (MTA) and Biodentine® are BioACTIVE materials used for pulp capping. Recently, dental researchers have produced BioACTIVE glass-incorporated light-curable pulp capping material. The study is aimed at evaluating the subcutaneous connective tissue reactions to MTA, Biodentine®, ACTIVA BioACTIVE Base/Liner. These materials were placed in polyethylene tubes and implanted into the dorsal connective tissue of Sprague Dawley rats. The presence of inflammation, predominant cell type, calcification, and thickness of fibrous connective tissue was recorded by histological examination 7, 30, and 60 days after the implantation procedure. Scores were defined as follows: 0 = none or few inflammatory cells, no reaction; 1 = p<0.05). Results. In terms of oedema, inflammation, fibrous capsule, and necrosis, no significant differences were found in any time period for any material. MTA and Biodentine® showed higher calcification than in the ACTIVA BioACTIVE on day 30, and the difference was statistically significant (p<0.05). After 60 days, while calcification was not seen in the control group, it was observed in the test groups. There was a statistically significant difference between the control and the others. Conclusion. All materials were well tolerated by the tissues in the 60-day evaluation period. One notable finding is the presence of dystrophic calcification in the connective tissue adjacent to the newly developed BioACTIVE Base/Liner material. Therefore, this new BioACTIVE Base/Liner material may be safely recommended to clinicians as a pulp capping material. |
| Databáze: | OpenAIRE |
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