Early Neurodevelopmental Findings Predict School Age Cognitive Abilities in Duchenne Muscular Dystrophy: A Longitudinal Study
| Autor: | Eugenio Mercuri, Adele D'Amico, Grazia D'Angelo, Maria Mallardi, Claudia Brogna, Daniela Chieffo, Marika Pane, Angela Berardinelli, Paolo Alfieri |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Longitudinal study medicine.medical_specialty Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA Duchenne muscular dystrophy Science Settore M-PSI/08 - PSICOLOGIA CLINICA Cognitive neuroscience fluids and secretions Settore MED/39 - NEUROPSICHIATRIA INFANTILE Cognition mental disorders Medicine Settore M-PSI/01 - PSICOLOGIA GENERALE Humans Longitudinal Studies Muscular dystrophy Child reproductive and urinary physiology Intelligence Tests Multidisciplinary Intelligence quotient business.industry Inglese medicine.disease Cognitive test Muscular Dystrophy Duchenne Child Preschool Cohort Physical therapy Female business Clinical psychology Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 8, p e0133214 (2015) |
| ISSN: | 1932-6203 |
| Popis: | ObjectiveNeurodevelopmental and cognitive difficulties are known to occur frequently in boys with Duchenne muscular dystrophy but so far none of the published studies have reported both early neurodevelopmental assessments and cognitive tests in the same cohort. The aim of the present longitudinal study was to establish the correlation between early neurodevelopmental assessments performed in preschool boys and the cognitive scales performed at school age or later.MethodsWe performed cognitive tests at school age (mean age 5.7 year ±1.7 SD) (69 months+19 SD) in a cohort of Duchenne boys, previously assessed using the Griffiths scales before the age of 4 years (mean age when the Griffiths scales were performed 30 months ±8.9 SD).ResultsThe range of total Developmental quotients on the Griffiths ranged between 56 and 116 (mean 89 ± 15.6 SD). The total Intelligence Quotients on the Wechsler scales ranged between 35 and 119 (mean 87 ± 17.2 SD). There was a significant correlation between the findings on the two scales. P = ConclusionsOur results confirm that Duchenne boys tend to slightly underperform on both neurodevelopmental and cognitive assessments. Early neurodevelopmental findings correlated with the cognitive results obtained at school age with a clear concordance between subscales exploring similar domains on the two scales. |
| Databáze: | OpenAIRE |
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