Cystatin-C and TGF-β levels in patients with diabetic nephropathy

Autor: Asli Dogruk Unal, Nilufer Bayraktar, Nilgun Guvener Demirag, Osman Kostek, Mumtaz Takir
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Urinary system
Renal function
Diabetic nephropathy
030204 cardiovascular system & hematology
lcsh:RC870-923
urologic and male genital diseases
Gastroenterology
Excretion
03 medical and health sciences
0302 clinical medicine
Transforming Growth Factor beta
TGF-β1
Internal medicine
medicine
Albuminuria
Humans
Diabetic Nephropathies
030212 general & internal medicine
Cystatin C
Cistatina C
Aged
biology
business.industry
Normoalbuminuria
Type 2 Diabetes Mellitus
Middle Aged
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
female genital diseases and pregnancy complications
Cross-Sectional Studies
Endocrinology
Diabetes Mellitus
Type 2
Nephrology
biology.protein
Nefropatía diabética
Biomarker (medicine)
Female
Microalbuminuria
business
TGF-beta 1
Biomarkers
Glomerular Filtration Rate
Zdroj: Nefrología, Vol 36, Iss 6, Pp 653-659 (2016)
Nefrología (English Edition), Vol 36, Iss 6, Pp 653-659 (2016)
ISSN: 0211-6995
DOI: 10.1016/j.nefro.2016.06.011
Popis: Objective: To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-beta levels. Methods: Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results: 78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate. Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p < 0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-beta 1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r = -0.892, p < 0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r = -0.726, p=0.001). Conclusions: Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy. (C) 2016 Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Nefrologia.
Databáze: OpenAIRE
Externí odkaz: