Inflammatory bowel disease and serum beta-N-acetylhexosaminidase
| Autor: | Eshchar J, Neuman M, E Scapa |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Adolescent medicine.drug_class medicine.medical_treatment Inflammation Disease Biology Biochemistry Inflammatory bowel disease Ileostomy Crohn Disease Liver Function Tests medicine Macrophage Humans Aged chemistry.chemical_classification Aged 80 and over Bile acid Macrophages Ileitis Middle Aged medicine.disease Ulcerative colitis digestive system diseases beta-N-Acetylhexosaminidases Enzyme chemistry Immunology Colitis Ulcerative Female medicine.symptom Lysosomes |
| Zdroj: | Enzyme. 43(3) |
| ISSN: | 0013-9432 |
| Popis: | Serum beta-N-acetylhexosaminidase levels in 49 patients with inflammatory bowel disease (IBD; 23 patients with ulcerative colitis, 10 with Crohn's disease, and 16 with ileostomy after total proctocolectomy) as well as in healthy normal controls were determined. They were found to be significantly elevated in 91% of all patients, disregarding the state of activity of the disease. It seems most likely that activated macrophages are the source of this lysosomal hydrolase in the serum of IBD patients since other theoretical possibilities, like damaged hepatocytes or elevated serum bile acid levels, are not relevant for these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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