Identification of SNP c.-22G>A in the melanophilin gene from a dog with color dilution alopecia: case report
| Autor: | Mariana Isa Poci Palumbo, Tessie Beck Martins, N.B. Messas, P.V. Leal, Carlos Alberto do Nascimento Ramos, L.M. Santos, L.A. Miyasato |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
integumentary system Secondary infection Dachshund Mutant Single-nucleotide polymorphism Papule Biology Molecular biology mendelian inheritance dermatology Melanin 03 medical and health sciences Basal (phylogenetics) 030104 developmental biology genotyping skin diseases Melanophilin medicine sense organs lcsh:Animal culture medicine.symptom lcsh:SF1-1100 |
| Zdroj: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Vol 69, Iss 6, Pp 1503-1507 |
| ISSN: | 1678-4162 |
| DOI: | 10.1590/1678-4162-9710 |
| Popis: | Mutant color alopecia is an ectodermical defection of color dilution, characterized by partial alopecia, dry, shine-less hair, and peeling and papule. Melanization damages also occur on the cortical structure of the affected hair. The animals affected have big melanin grains with irregular shape on the basal keratinocytes, also on the hair matrix cells and rod. Therefore, there is not a specific treatment that makes any difference on the syndrome evolution. Although in some animals, it is possible to use weekly showers with benzyl peroxide to reduce seborrhea formation and secondary infections. There is evidence that the condition in dogs is caused by a single nucleotide polymorphism in the gene encoding the melanophilin protein. In the present study the identification of the SNP c.-22G>A in the melanophilin gene of a Dachshund breed dog with clinical and histopathologic evidence of color dilution alopecia is reported. |
| Databáze: | OpenAIRE |
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