The Clinical Significance of OPG/sRANKL Ratio in Thalassemia Patients Suffering from Osteopenia or Osteoporosis in Egyptian Patients
| Autor: | Hosam Salah, Maha Atfy, Jehan Saeed, Hosam Mansor, Mervat Atfy, Ayman Fathy |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male musculoskeletal diseases congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Adolescent Thalassemia Immunology Osteoporosis Enzyme-Linked Immunosorbent Assay Gastroenterology Young Adult Osteoprotegerin hemic and lymphatic diseases Internal medicine medicine Humans Clinical significance Child biology business.industry RANK Ligand beta-Thalassemia Case-control study General Medicine medicine.disease Osteopenia Bone Diseases Metabolic Endocrinology RANKL Case-Control Studies Child Preschool biology.protein Etiology Egypt Female business Biomarkers |
| Zdroj: | Immunological Investigations. 39:820-832 |
| ISSN: | 1532-4311 0882-0139 |
| Popis: | Osteopenia and osteoporosis are considered major health problems in patients suffering from thalassemia due to increased life expectancy of those patients. Osteoprotegerin (OPG) and receptor activator of NF-kappa-B ligand (RANKL) have been recently implicated in the pathogenesis of various types of osteoporosis. The aim of this study is to evaluate the role of serum OPG/RANKL ratio in patients suffering from thalassemia complicated with osteoporosis. Serum OPG and RANKL were measured in thalassemia patients and 20 healthy control subjects, using ELISA methods. Stastistically, the results demonstrate lower OPG and OPG/RANKL ratio in patients suffering from thalassemia with documented osteopenia or osteoporosis in comparison with control group and patients suffering from thalassemia without osteopenia or osteoporosis. OPG/RANKL ratio could become a promising rapid and cheap screening marker for osteopenia or osteoporosis in patients suffering from thalassemia. Furthermore, OPG may become a therapeutic option in treatment of osteoporosis of various etiologies including thalassemia. |
| Databáze: | OpenAIRE |
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