Connective Tissue Degeneration: Mechanisms of Palmar Fascia Degeneration (Dupuytren's Disease)
| Autor: | M. Kreulen, Ian M. Clark, Marianna Kruithof-de Julio, Miryam C. Obdeijn, Annemarie L. Dorjée, Peter Kloen, Felice Rivellese, Sofia Karkampouna, Adrian Chojnowski |
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| Přispěvatelé: | Amsterdam Cardiovascular Sciences, Other Research, Plastic, Reconstructive and Hand Surgery, Orthopaedic Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Connective Tissue Disorder Pathology medicine.medical_specialty Contracture Connective tissue Degeneration (medical) Extracellular matrix 03 medical and health sciences 0302 clinical medicine Fibrosis Regeneration Medicine Stem/Progenitor Cells Biology and Regeneration (I Kalajzic Section Editor) Inflammation business.industry Dupuytren’s Regeneration (biology) General Engineering medicine.disease body regions 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis medicine.symptom business Wound healing |
| Zdroj: | Current Molecular Biology Reports Current molecular biology reports, 2(3), 133-140 |
| ISSN: | 2198-6428 |
| DOI: | 10.1007/s40610-016-0045-3 |
| Popis: | Dupuytren’s disease is a connective tissue disorder of the hand causing excessive palmar fascial fibrosis with associated finger contracture and disability. The aetiology of the disease is heterogeneous, with both genetic and environmental components. The connective tissue is abnormally infiltrated by myofibroblasts that deposit collagen and other extracellular matrix proteins. We describe the clinical profile of Dupuytren’s disease along with current therapeutic schemes. Recent findings on molecular and cellular parameters that are dysregulated in Dupuytren’s disease, which may contribute to the onset of the disease, and the role of resident inflammation promoting fibrosis, are highlighted. We review recent literature focusing on non-myofibroblast cell types (stem cell-like cells), their pro-inflammatory and pro-fibrotic role that may account for abnormal wound healing response. |
| Databáze: | OpenAIRE |
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