K27M midline gliomas display malignant progression by imaging and histology
| Autor: | Franziska Vettermann, Peter Bartenstein, Nathalie L. Albert, Julia E. Neumann, Ulrich Schüller, Mario M. Dorostkar, Armin Giese, Bogdana Suchorska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty genetics [Glioma] Histology Adolescent pathology [Brain Neoplasms] Central nervous system Low grade astrocytoma genetics [Mutation] Biology Pathology and Forensic Medicine Histones 03 medical and health sciences Young Adult 0302 clinical medicine Physiology (medical) medicine Humans ddc:610 Young adult Child diagnostic imaging [Glioma] Brain Neoplasms Glioma Middle Aged medicine.disease Spinal cord genetics [Histones] genetics [Brain Neoplasms] 030104 developmental biology medicine.anatomical_structure Neurology Child Preschool Mutation Disease Progression Female Neurology (clinical) diagnostic imaging [Brain Neoplasms] Malignant progression Who classification 030217 neurology & neurosurgery pathology [Glioma] Glioblastoma |
| Zdroj: | Neuropathology & applied neurobiology 43(5), 458-462 (2017). doi:10.1111/nan.12371 |
| DOI: | 10.1111/nan.12371 |
| Popis: | K27M midline gliomas are diffuse gliomas that usually occur in children and young adults and arise in midline structures of the brain, the brain stem and the spinal cord. They are defined by point mutations within the chromatin modifiers H3 and are usually associated with a bad clinical outcome [1,2,3]. As such, they are represented as a new separate entity in the new version of the WHO classification for tumors of the central nervous system. Interestingly, these tumors display a huge histological variability [4] and diagnoses currently range from low grade astrocytoma (WHO-grade II) to glioblastoma (WHO-grade IV). This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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