| Autor: |
Noha A. El-Bassiouny, Maged W. Helmy, Mostafa Alaa Eldin Hassan, Gehan A. Khedr |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical Breast Cancer. 22:359-366 |
| ISSN: |
1526-8209 |
| Popis: |
The primary objective of this study was to investigate the potential protective effect of Vitamin D (Vit D) on DOX induced cardio toxicity (DIC) in early breast cancer patients receiving adjuvant DOX based chemotherapy (AC). The secondary objective was to investigate the anti-inflammatory effect of Vit D by measuring serum IL-6 and its correlation with cardio toxicity.This study was carried out on 150 newly diagnosed women with breast cancer who were planned to receive four cycles of adjuvant AC chemotherapy regimen (60 mg/mVit D supplementation in Vit D group patients was associated with a significant decrease (P0.001) in serum levels of LDH, cTnT, and IL-6 compared to the control group .The present work provides a promising clinical evidence to support the cardio protective effects of Vit D against DIC through attenuating the evoked pro-inflammatory cytokines induced by DOX. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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