Urtica spp.: Phenolic composition, safety, antioxidant and anti-inflammatory activities
| Autor: | Ana Rita Carvalho, Joana Liberal, Maria Teresa Cruz, Maria do Carmo Lopes, Gustavo Costa, João A.V. Prior, Artur Figueirinha, Maria Teresa Batista |
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| Rok vydání: | 2017 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization food.ingredient Cell Survival Anti-Inflammatory Agents 01 natural sciences Antioxidants Mice chemistry.chemical_compound food Phenols Picrates Botany Animals Humans Benzothiazoles Urticaceae Urtica dioica Chromatography High Pressure Liquid Nitrites chemistry.chemical_classification biology Traditional medicine Plant Extracts 010405 organic chemistry Macrophages Biphenyl Compounds 010401 analytical chemistry Urtica Hep G2 Cells biology.organism_classification Hydroxycinnamic acid 0104 chemical sciences RAW 264.7 Cells chemistry Urtica urens Polyphenol Apigenin Sulfonic Acids Luteolin Food Science |
| Zdroj: | Food Research International. 99:485-494 |
| ISSN: | 0963-9969 |
| DOI: | 10.1016/j.foodres.2017.06.008 |
| Popis: | Urtica dioica and other less studied Urtica species (Urticaceae) are often used as a food ingredient. Fifteen hydroxycinnamic acid derivatives and sixteen flavonoids, flavone and flavonol-type glycosides were identified in hydroalcoholic extracts from aerial parts of Urtica dioica L., Urtica urens L. and Urtica membranacea using HPLC-PDA-ESI/MSn. Among them, the 4-caffeoyl-5-p-coumaroylquinic acid and three statin-like 3-hydroxy-3-methylglutaroyl flavone derivatives were identified for the first time in Urtica urens and U. membranacea respectively. Urtica membranacea showed the higher content of flavonoids, mainly luteolin and apigenin C-glycosides, which are almost absent in the other species studied. In vitro, Urtica dioica exhibited greater antioxidant activity but Urtica urens exhibited stronger anti-inflammatory potential. Interestingly, statin-like compounds detected in Urtica membranacea have been associated with hypocholesterolemic activity making this plant interesting for future investigations. None of the extracts were cytotoxic to macrophages and hepatocytes in bioactive concentrations (200 and 350μg/mL), suggesting their safety use in food applications. |
| Databáze: | OpenAIRE |
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