Decreased excretion of ring-A reduced steroid metabolites by hypertensive females
| Autor: | A.C. Dey, I.R. Senciall |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
medicine.medical_specialty Chromatography Gas medicine.medical_treatment Urine Tritium Biochemistry Elevated blood Steroid Excretion Internal medicine medicine Methods Humans Carbon Radioisotopes Hypertensive group Aged Glucuronidase Chromatography Chemistry Middle Aged Chromatography Ion Exchange Silicon Dioxide 17-Ketosteroids Endocrinology Hypertension Female Reductase activity Chromatography Thin Layer Sulfatases Oxidation-Reduction |
| Zdroj: | Biochemical medicine. 12(3) |
| ISSN: | 0006-2944 |
| Popis: | The excretion of 5α- and 5β-reduced 11-deoxy and 11-oxy-17-keto-steroids, and 17-ketogenic steroids in the urine of 9 normal and 13 essential hypertensive females has been investigated by gas liquid chromatography. A significant reduction in the excretion of a 5β-reduced 11-deoxy-17-ketosteroid by essential hypertensives was confirmed. The proportions of 5β-reduced metabolites of 11-oxy-17-ketosteroids were not altered by hypertension, whereas they were significantly increased in the 17-ketogenic fraction. Similar amounts of 5α-reduced metabolites of 11-deoxy-17-ketosteroids were excreted by both groups, and greater amounts of 11-oxy-17-ketosteroids and 17-ketogenic steroids by the hypertensive group. The differences in Δ 4 -5 α -and Δ 4 -5 β -reductase activity, inferred from the proportions of metabolites excreted, may be the result of a differential effect of the elevated blood pressure on substrate specific Δ 4 -5-reductases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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