Canine Hemangiosarcoma Treated with Standard Chemotherapy and Minocycline
| Autor: | Karin Sorenmo, Lili Duda, Lisa Barber, Kim Cronin, Carl Sammarco, Amy Usborne, Michael Goldschmidt, Frances Shofer |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Skin Neoplasms General Veterinary Splenic Neoplasms Hemangiosarcoma Angiogenesis Inhibitors Minocycline Survival Analysis Anti-Bacterial Agents Neoplasms Multiple Primary Dogs Doxorubicin Antineoplastic Combined Chemotherapy Protocols Animals Female Dog Diseases Prospective Studies Retroperitoneal Neoplasms Cyclophosphamide |
| Zdroj: | Journal of Veterinary Internal Medicine. 14:395-398 |
| ISSN: | 1939-1676 0891-6640 |
| DOI: | 10.1111/j.1939-1676.2000.tb02247.x |
| Popis: | Standard treatments for canine hemangiosarcoma include surgery and chemotherapy with doxorubicin, but in spite of treatment most dogs with this disease die within 6 months of diagnosis. Tumor growth and metastasis are angiogenesis dependent. Antiangiogenic drugs such as minocycline may provide therapeutic benefits in cancer patients. The purpose of this prospective study was to evaluate the efficacy of chemotherapy with doxorubicin and minocycline, an antiangiogenic agent, in dogs with hemangiosarcoma. Eighteen dogs with histologically confirmed hemangiosarcoma of any stage were treated with doxorubicin, cyclophosphamide, and minocycline. Complete staging was performed before and during the treatment period to assess remission status and response to therapy. No statistically significant difference was found in survival between the dogs treated with chemotherapy and minocycline, and historical controls consisting of dogs that received chemotherapy alone. Postmortem examination revealed widespread metastasis, suggesting that minocycline is ineffective as a single antiangiogenic agent in canine hemangiosarcoma. |
| Databáze: | OpenAIRE |
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